論文業績
英文原著
- Olivera P, Zuily S, Kotze P, Regnault V,Al Awadhi S,Bossuyt P, Gearry R, Ghosh S, Kobayashi T, Lacolley P, Louis E, Magro F, Ng S, Papa A, Raine T, Teixeira F, Rubin D, Danese S, and Laurent Peyrin-Biroulet. International consensus on the prevention of venous and arterial thrombotic events in patients with inflammatory bowel disease. Nature Reviews Gastroenterology and Hepatology. 18(12):857-873. 2021
- Hibi T, Kamae I, Pinton P, Ursos L, Iwakiri R, Hather G, Patel H. Efficacy of biologic therapies for biologic-naïve Japanese patients with moderately to severely active ulcerative colitis: a network meta-analysis. Intestinal Research 19(1):53-61. 2021
- Watanabe C, Nagahori M, Fujii T, Yokoyama K, Yoshimura N, Kobayashi T, Yamagami H, Kitamura K, Takashi K, Nakamura S, Naganuma M, Ishihara S, Esaki M, Yonezawa M, Kunisaki R, Sakuraba A, Kuji N, Miura S, Hibi T, Suzuki Y, Hokari R. Non-adherence to Medications in Pregnant Ulcerative Colitis Patients Contributes to Disease Flares and Adverse Pregnancy Outcomes. Dig Dis Sci. 66(2):577-586. 2021
- Higashiyama M ,Komoto S, Suzuki Y, Watanabe M, Hibi T, Miura S, Hokari R. Relation of Geriatric Nutritional Risk Index With Clinical Risks in Elderly-Onset Ulcerative Colitis. J Gastroenterol Hepatol 36(1):163-170. 2021
- Uchino M, Ikeuchi H, Hata K, Minagawa T, Horio Y, Kuwahara R, Nakamura S, Watanabe K, Saruta M, Fujii T, Kobayashi T, Sugimoto K, Hirai F, Esaki M, Hiraoka S, Matsuoka K, Shinzaki S, Matsuura M, Inoue N, Nakase H, Watanabe M. Intestinal cancer in patients with Crohn's disease: A systematic review and meta-analysis. J Gastroenterol Hepatol 36(2):329-336. 2021
- Crooks B, McLaughlin J, Matsuoka K ,Kobayashi T , Yamazaki H , Limdi JK. The dietary practices and beliefs of people living with inactive ulcerative colitis. Eur J Gastroenterol Hepatol 33(3):372-379. 2021
- Uchino M, Ikeuchi H, Hata K, Minagawa T, Horio Y, Kuwahara R, Nakamura S, Watanabe K, Saruta M, Fujii T, Kobayashi T, Sugimoto K, Hirai F, Esaki M, Hiraoka S, Matsuoka K, Shinzaki S, Matsuura M, Inoue N, Nakase H, Watanabe M. Does anti-tumor necrosis factor alpha prevent the recurrence of Crohn's disease? Systematic review and meta-analysis. J Gastroenterol Hepatol 36(4):864-872. 2021
- Vermeire S, Su C, Lawendy N, Kobayashi T , Sandborn W J, Rubin D T, Modesto I, Gardiner S , Kulisek N, Zhang H, Wang W, Panés J. Outcomes of Tofacitinib Dose Reduction in Patients with Ulcerative Colitis in Stable Remission from the Randomized RIVETING Trial J Crohns Colitis 15(7):1130-1141. 2021
- Yoshihara T, Shinzaki S, Amano T, Iijima H, Takehara T, Inoue N, Uchino M, Esaki M, Kobayashi T, Saruta M, Sugimoto K, Nakamura S, Hata K, Hirai F, Hiraoka S, Fujii T, Matsuura M, Matsuoka K, Watanabe K, Nakase H, Watanabe M. Concomitant use of an immunomodulator with ustekinumab as an induction therapy for Crohn's disease: A systematic review and meta-analysis. J Gastroenterol Hepatol 36(7):1744-1753. 2021
- Suzuki K , Kakuta Y , Naito T , Takagawa T , Hanai H, Araki H , Sasaki Y , Sakuraba H, Sasaki M , Hisamatsu H, Motoya S, Matsumoto T ,Onodera M , Ishiguro Y , Nakase H , Andoh A, Hiraoka S ,Shinozaki M , Fujii T , Katsurada T , Kobayashi T, Fujiya M, Otsuka T , Oshima N , Suzuki Y , Sato Y , Hokari R , Noguchi M , Ohta Y , Matsuura M, Kawai Y , Tokunaga K , Nagasaki M , Kudo H , Minegishi N , Okamoto D , Shimoyama Y , Moroi R , Kuroha M , Shiga H , Dalin Li , Dermot P B McGovern , Kinouchi Y , Masamune A , MENDEL study group. Genetic Background of Mesalamine-induced Fever and Diarrhea in Japanese Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis. Jan 27;izab004. doi: 10.1093/ibd/izab004. Online ahead of print. 2021
- Kita T, Ashizuka S, Ohmiya N, Yamamoto T, Kanai T, Motoya S, Hirai F, Nakase H, Moriyama T, Nakamura M, Suzuki Y, Kanmura S, Kobayashi T, Ohi H, Nozaki R, Mitsuyama K. Yamamoto S, Inatsu H, Watanbe K, Hibi T, Kitamura K. Adrenomedullin for steroid-resistant ulcerative colitis: a randomized, double-blind, placebo-controlled phase-2a clinical trial. J Gastroenterol. 56(2):147–157. 2021
- Matsubayashi M, Kobayashi T, Okabayashi S, Nakano M, Sagami S, Ozaki R, Kiyohara H, Morikubo H, Asonuma K, Miyatani Y, Maeda S, Hibi T. Determining the usefulness of Capsule Scoring of Ulcerative Colitis in predicting relapse of inactive ulcerative colitis. J Gastroenterol Hepatol. 36(4):943-950. 2021
- Sagami S, Kobayashi T, Miyatani Y, Okabayashi S, Yamazaki H, Kinoshita K, Alocca M, Kunisaki R, Ramaswamy PK, Shiraki M, Hibi T, Kataoka Y. Accuracy of Ultrasound for Evaluation of Colorectal Segments in Patients with Inflammatory Bowel Diseases: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 19(5):908-921. 2021
- Shinzaki S, Matsuoka K, Tanaka H, Takeshima F, Kato S, Torisu T, Ohta Y, Watanabe K, Nakamura S, Yoshimura N, Kobayashi T, Shiotani A, Fumihito H, Hiraoka S, Watanabe M, Matsuura M, Nishimoto S, Mizuno S, Iijima H, Takehara T, Naka T, Kanai T, Matsumoto T. Leucine-rich alpha-2 glycoprotein is a potential biomarker to monitor disease activity in inflammatory bowel disease receiving adalimumab: PLANET study. J Gastroenterol 56(6):560-569. 2021
- Shen B, Kochhar GS, Navaneethan U, Cross RK, Farraye FA, Iacucci M, Schwartz DA, Gonzalez-Lama Y, Schairer J, Kiran RP, Kotze PG, Kobayashi T, Bortlik M, Liu X, Levy AN, González Suárez B, Tang SJ, Coelho-Prabhu N, Lukas M, Bruining DH, El-Hachem S, Charles RJ, Chen Y, Sood A, Mao R, Loras C, Dulai PS, Picoraro JA, Chiorean M, Lukas M, Shergill A, Silverberg MS, Sandborn WJ, Bernstein CN. Endoscopic evaluation of surgically altered bowel in inflammatory bowel disease: a consensus guideline from the Global Interventional Inflammatory Bowel Disease Group. Lancet Gastroenterol Hepatol 6(6):482-497. 2021
- Nakase H, Uchino M, Shinzaki S, Matsuura M, Matsuoka K, Kobayashi T, Saruta M, Hirai F, Hata K, Hiraoka S, Esaki M, Sugimoto K, Fuji T, Watanabe K, Nakamura S, Inoue N, Itoh T, Naganuma M, Hisamatsu T, Watanabe M, Miwa H, Enomoto N, Shimosegawa T, Koike K. Evidence-based clinical practice guidelines for inflammatory bowel disease 2020. J Gastroenterol. 56(6):489-526. 2021
- Asonuma K, Kobayashi T, Nakano M, Sagami S, Kiyohara H, Matsubayashi M, Morikubo H, Miyatani Y, Okabayashi S, Yamazaki H, Kuroki Y, Hibi T. Residual Short-Segment Distal Inflammation Has No Significant Impact on the Major Relapse of Extensive Ulcerative Colitis. Inflamm Bowel Dis. Apr 13;izab062.doi:10.1093/ibd/izab062. Online ahead of print. 2021
- D'Amico F, Rubin DT, Kotze PG, Magro F, Siegmund B, Kobayashi T, Olivera PA, Bossuyt P, Pouillon L, Louis E, Domènech E, Ghosh S, Danese S, Peyrin-Biroulet L. International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases. United European Gastroenterol J. 9(4):451-460. 2021
- Kobayashi T, Motoya S, Nakamura S, Yamamoto T, Nagahori M, Tanaka S, Hisamatsu T, Hirai F, Nakase H, Watanabe K, Matsumoto T, Tanaka M, Abe T, Suzuki Y, Watanabe M, Hibi T, on behalf of the HAYABUSA Study Group. Discontinuation of infliximab in patients with ulcerative colitis in remission (HAYABUSA): a multicentre, open-label, randomised controlled trial. Lancet Gastroenterol Hepatol 6(6):429-437. 2021
- Morikubo H, Kobayashi T, OzakiR, Okabayashi S, Kuronuma S, Takeuchi O, Shiba T, Kiyohara H, Matsubayashi M, Sagami S, Nakano M, Ikezaki O, Hisamatsu T, Tanaka Y, Hibi T. Differential effects of mesalazine formulations on thiopurine metabolism through thiopurine S-methyltransferase inhibition. J Gastroenterol Haepatol 36(8)2116-2124. 2021
- Kobayashi T (Corresponding author),Udagawa E, Hibi T. Lack of Increased Risk of Lymphoma with Thiopurine Therapy Regardless of Dose and Duration of Treatment in Japanese Patients with Inflammatory Bowel Diseases. Digestion Online ahead of print. 2021
- Kobayashi T, Uda A, Udagawa E, Hibi T. Lack of Increased Risk of Lymphoma by Thiopurines or Biologics in Japanese Patients with Inflammatory Bowel Disease: A Large-Scale Administrative Database Analysis. J Crohns Colitis. 14(5):617-623. 2020
- Kakuta Y, Izumiyama Y, Okamoto D, Nakano T,Ichikawa R, Naito T, Moroi R, Kuroha M, Kanazawa Y, Kimura T, Shiga H, Kudo H, Minegishi N, Kawai Y, Tokunaga K,Nagasaki M,Kinouchi Y, Suzuki Y, Masasmune A; MENDEL study group(Kobayashi T). High-resolution melt analysis enables simple genotyping of complicated polymorphisms of codo n 18 rendering the NUDT15 diplotype. J Gastroenterol. 55(1):67-77. 2020
- Naganuma M, Sugimoto S, Fukuda T, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Abe T, Suzuki Y, Kanai T; INDIGO Study Group. Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study. J Gastroenterol. 55(2):169-180. 2020
- Sandborn WJ, Baert F, Danese S, Krznarić Z, Kobayashi T, Yao X, Chen J, Rosario M, Bhatia S, Kisfalvi K, D’Haens G, Vermeire S. Efficacy and Safety of a New Vedolizumab Subcutaneous Formulation in Ulcerative Colitis: VISIBLE 1 Randomized Trial. Gastroenrterol. 158(3):562-572. 2020
- Naganuma M, Kobayashi T, Nasuno M, Motoya S, Kato S, Matsuoka K, Hokari R, Watanabe C, Sakamoto H, Yamamoto H, Sasaki M, Watanabe K, Iijima H, Endo Y, Ichikawa H, Ozeki K, Tanida S, Ueno N, Fujiya M, Sako M, Takeuchi K, Sugimoto S, Abe T, Hibi T, Suzuki Y, Kanai T. Significance of Conducting 2 Types of Fecal Tests in Patients with Ulcerative Colitis. Clin Gastroenterol Hepatol. 18(5):1102-1111. 2020
- Kobayashi T, Udagawa E, Uda A, Hibi T, Hisamatsu T. Impact of immunomodulator use on treatment persistence in patients with ulcerative colitis: a claims database analysis. J Gastroenterol Hepatol. 35(2):225-232. 2020
- Nanki K, Fujii M, Shimokawa M, Matano M, Nishikori S, Date S, Takano A, Toshimitsu K , Ohta Y, Takahashi S, Sugimoto S, Ishimaru K, Kawasaki K, Nagai Y, Ishii R, Yoshida K1, Sasaki N, Hibi T, Ishihara S, Kanai T, Sato T. Somatic inflammatory gene mutations in human ulcerative colitis epithelium. Nature. 577(7789):254-259. 2020
- Saruta M, Park DI, Kim YH, Yang SK, Jang BI, Cheon JH, Im JP, Kanai T, Katsuno T, Ishiguro Y, Nagaoka M, Isogawa N, Li Y, Banerjee A, Ahmad A, Hassan-Zahraee M, Clare R, Gorelick KJ, Cataldi F, Watanabe M, Hibi T. Anti-MAdCAM-1 antibody (PF-00547659) for active refractory Crohn's disease in Japanese and Korean patients: the OPERA study. Intest Res. 18(1):45-55. 2020
- Hibi T, Naganuma M, Oda E, Yamada Y, Chujoh Y, Yoshihara R, Watanabe M. Predictive factors for achievement of mucosal healing by budesonide 2-mg foam in ulcerative colitis: a pooled analysis of data from two clinical trials. Intest Res. 18(1):56-68. 2020
- Hibi T, Ishibashi T, Ikenoue Y, Yoshihara R, Nihei A, Kobayashi T. Ulcerative Colitis:Disease Burden,Impact on Daily Life,anc Reluctance to Consult Medical Professionals:Results from a Japanese Internet Survey. Inflammatory Intestinal Diseases 5(1):27-35. 2020
- S Bamba, R Sakemi, T Fujii, T Takkeda, S Fujioka, K Takenaka, H Kitamoto, S Umezawa, H Sakuraba, T Inokuchi, N Fukata, S Mizuno , M Yamashita , S Shinzaki , H Tanaka, H Takedatsu, R Ozaki, K Moriya, M Ishii, T Kinjo ,K Ozeki, M Ooi, R Hayashi, K Kakimoto, Y Shimodate, K Kitamura, A Yamada , A Sonoda, Y Nishida, K Yoshioka, S Ashizuka, F Takahashi, T Shimokawa, T Kobayashi, A Andoh, T Hibi. A Nationwide, Multi-Center, Retrospective Study of Symptomatic Small Bowel Stricture in Patients With Crohn's Disease. J Gastroenterol. 55(6):615-626. 2020
- Naganuma M, Yokoyama Y, Motoya S, Watanabe K, Sawada K, Hirai F, Yamamoto T, Hanai H, Omori T, Kanai T, Hibi T; CAPTAIN study Group. Efficacy of Apheresis as Maintenance Therapy for Patients With Ulcerative Colitis in an Open-Label Prospective Multicenter Randomised Controlled Trial. J Gastroenterol. 55(4):390-400. 2020
- Watanabe K, Motoya S, Ogata H, Kanai T, Matsui T, Suzuki Y, Shikamura M, Sugiura K, Oda K, Hori T, Araki T, Watanabe M, Hibi T. Effects of Vedolizumab in Japanese Patients With Crohn's Disease: A Prospective, Multicenter, Randomized, Placebo-Controlled Phase 3 Trial With Exploratory Analyses. J Gastroenterol. 55(3):291-306. 2020
- Kobayashi T, Siegmund B, Le Berre C, Wei SC, Ferrante M, Shen B, Bernstein CN, Danese S, Peyrin-Biroulet L, and Hibi T. Ulcerative colitis. Nat Rev Dis Primers 6(1):74. 2020
- Kobayashi T, Ito H, Ashida T, Yokoyama T, Nagahori M, Inaba T, Shikamura M, Yamaguchi T, Hori T, Pinton P, Watanabe M, Hibi T. Efficacy and safety of a new vedolizumab subcutaneous formulation in Japanese patients with moderately to severely active ulcerative colitis. Intest Res 2020 Aug 18. doi: 10.5217/ir.2020.00026. Online ahead of print. 2020
- Okabayashi S, Kobayashi T, Saito E, Toyonaga T, Ozaki R, Sagami S, Nakano M, Tanaka J, Yagisawa K, Kuronuma S, Takeuchi O, Hibi T. Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis. Intestinal Research. 17(2):218-226. 2019
- Hibi T, Motoya S, Ashida T, Sai S, Sameshima Y, Nakamura S, Maemoto A, Nii M, Sullivan BA, Gasser RA, Suzuki Y. Efficacy and safety of abrilumab, α4β7 integrin inhibitor, in Japanese patients with moderate-to-severe ulcerative colitis: a phase II study. Intest Res. 17(3):375-386. 2019
- Hisamatsu T, Matsumoto T, Watanabe K, Nakase H, Motoya S, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T; DIAMOND study group. Concerns and side effects of azathioprine during adalimumab induction and maintenance therapy for Japanese patients with Crohn's disease: a sub-analysis of a prospective randomized clinical trial (DIAMOND study). J Crohns Colitis. 13(9):1097-1104. 2019
- Sagami S, Kobayashi T, Kikkawa N, Umeda S, Nakano M, Takahiko T, Okabayashi S, Hibi T. Combination of colonoscopy and magnetic resonance enterography is more useful for clinical decision making than colonoscopy alone in patients with complicated Crohn's disease. PLoS One. 14(2):e0212404. 2019
- Motoya S, Watanabe K, Ogata H, Kanai T, Matsui T, Suzuki Y, Shikamura M, Sugiura K, Oda K, Hori T, Araki T, Watanabe M, Hibi T. Vedolizumab in Japanese patients with ulcerative colitis: A Phase 3, randomized, double-blind, placebo-controlled study. PLoS One. Feb26;14(2).e0212989. 2019
- Sands BE, Sandborn WJ, Panaccione R, O'Brien CD, Zhang H, Johanns J, Adedokun OJ, Li K, Peyrin-Biroulet L, Van Assche G, Danese S, Targan S, Abreu MT, Hisamatsu T, Szapary P, Marano C; UNIFI Study Group (Kobayashi T). Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis. N Engl J Med. 381(13):1201-1214. 2019
- Oka A, Mishima Y, Liu B, Herzog JW, Steinbach EC, Kobayashi T, Plevy SE, Sartor RB. Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation. Cells. 21;8(10)1121. 2019
- Schreiner P, Neurath MF, Ng SC, El-Omar EM, Sharara AI, Kobayashi T, Hisamatsu T, Hibi T, Rogler G. Mechanism-Based Treatment Strategies for IBD: Cytokines, Cell Adhesion Molecules, JAK Inhibitors, Gut Flora, and More. Inflamm Intest Dis. Aug;4(3):79–96. 2019
- Yamazaki H, So R, Matsuoka K, Kobayashi T, Shinzaki S, Matsuura M, Okabayashi S, Kataoka Y, Tsujimoto Y, Furukawa TA, Watanabe N. Certolizumab pegol for induction of remission in Crohn's disease. Cochrane Database Syst Rev. Aug 29;8:CD012893. doi: 10.1002/14651858. 2019
- Nakagawa T, Kobayashi T, Nishikawa K, Yamada F, Asai S, Sameshima Y, Suzuki Y, Watanabe M, Hibi T. Infliximab biosimilar CT-P13 is interchangeable with its originator for patients with inflammatory bowel disease in real world practice. Intest Res. 17(4):504-515. 2019
- Hisamatsu T, Kato S, Kunisaki R, Matsuura M, Nagahori M, Motoya S, Esaki M, Fukata N, Inoue S, Sugaya T, Sakuraba H, Hirai F, Watanabe K, Kanai T, Naganuma M, Nakase H, Suzuki Y, Watanabe M, Hibi T, Nojima M, Matsumoto T; DIAMOND2 Study Group(Kobayashi T). Withdrawal of thiopurines in Crohn's disease treated with scheduled adalimumab maintenance: a prospective randomised clinical trial (DIAMOND2). J Gastroenterol. Oct;54(10):860-870. 2019
- Yoshida A, Kamata N, Yamada T, Yokoyama Y, Omori T, Fuji T, Hayashi Rm Kinjoh T, Matsui A, Fukata N, Takahashi S, Sakemil R, Ogata N, Ashizuka S, Bamba S, Ooi M, Kanmura S, Endo K, Yoshino T, Tanaka H, Morizane T, Shinzaki S, Kobayashi T. Risk Factors for Mortality in Pneumocystis jirovecii Pneumonia in Patients with Inflammatory Bowel Disease. Inflamm Intest Dis. 3(4):167-172. 2019
- Naganuma M, Sugimoto S, Suzuki H, Matsuno Y, Araki T, Shimizu H, Hayashi R, Fukuda T, Nakamoto N, Iijima H, Nakamura S, Kataoka M, Tamura Y, Tatsumi K, Hibi T, Suzuki Y, Kanai T; INDIGO survey Group. Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanese nationwide survey. J Gastroenterol. 54(10):891-896. 2019
- Suzuki Y, Watanabe M, Matsui T, Motoya S, Hisamatsu T, Yuasa H, Tabira J, Isogawa N, Tsuchiwata S, Arai S, Hibi T. Tofacitinib as Induction and Maintenance Therapy in Japanese Patients With Active Ulcerative Colitis. Inflamm Intest Dis. Oct;4(4):131-143. 2019
- Hajime Yamazaki, Katsuyoshi Matsuoka,Jovelle Fernandez,Toshifumi Hibi,Mamoru Watanabe,Tadakazu Hisamatsu, Shunichi Fukuhara1. Ulcerative Colitis Outcomes Research in Japan: Protocol for an Observational Prospective Cohort Study of YOURS (YOu and Ulcerative Colitis: Registry and Social Network). BMJ Open Sep 8;9(9):e030134. 2019
- Naganuma M, Aoyama N, Tada T, Kobayashi K, Hirai F, Watanabe K, Watanabe M, Hibi T. Complete mucosal healing of distal lesions induced by twice-daily budesonide 2-mg foam promoted clinical remission of mild-to-moderate ulcerative colitis with distal active inflammation: double-blind, randomized study. J Gastroenterol 53(4):494-506. 2018
- Kobayashi T, Matsuoka K, Yokoyama Y, Nakamura T, Ino T, Numata T, Shibata H, Aoki H, Matsuno Y, Hibi T. A multicenter, retrospective, observational study of the clinical outcomes and risk factors for relapse of ulcerative colitis at 1 year after leukocytapheresis. J Gastroenterol 53(3):387-396. 2018
- Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Nishikawa M, Yamamoto J, Hibi T, Miura S, Minamino T, Oike Y, Hokari R, Kanai T. Aortic carboxypeptidase-like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis. J Clin Invest. 128(4):1581-1596. 2018
- Tanaka H, Kamata N, Yamada A, Endo K, Fujii T, Yoshino T, Sugaya T, Yokoyama Y, Bamba S, Umeno J, Yanai Y, Ishii M, Kawaguchi T, Shinzaki S, Toya Y, Kobayashi T, Nojima M, Hibi T; ADJUST study group. Long-term retention of adalimumab treatment and associated prognostic factors for 1189 patients with Crohn's disease. J Gastroenterol Hepatol. 33(5)1031-1038. 2018
- Park DI, Hisamatsu T, Chen M, Ng SC, Ooi CJ, Wei SC, Banerjee R, Hilmi IN, Jeen YT, Han DS, Kim HJ, Ran Z, Wu K, Qian J, Hu PJ, Matsuoka K, Andoh A, Suzuki Y, Sugano K, Watanabe M, Hibi T, Puri AS, Yang SK. Asian Organization for Crohn's and Colitis and Asian Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 1: Risk assessment. J Gastroenterol Hepatol. 33(1):20-29. 2018
- Park DI, Hisamatsu T, Chen M, Ng SC, Ooi CJ, Wei SC, Banerjee R, Hilmi IN, Jeen YT, Han DS, Kim HJ, Ran Z, Wu K, Qian J, Hu PJ, Matsuoka K, Andoh A, Suzuki Y, Sugano K, Watanabe M, Hibi T, Puri AS, Yang SK. Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 2: Management. J Gastroenterol Hepatol. 33(1):30-36. 2018
- Umeno J, Esaki M, Hirano A, Fuyuno Y, Ohmiya N, Yasukawa S, Hirai F, Kochi S, Kurahara K, Yanai S, Uchida K, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Nagayama M, Yamamoto H, Abukawa D, Kakuta F, Onodera K, Matsui T, Hibi T, Yao T, Kitazono T, Matsumoto T; CEAS study group. Clinical features of chronic enteropathy associated with SLCO2A1 gene: a new entity clinically distinct from Crohn's disease. J Gastroenterol. 53(8):907-915. 2018
- Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T; INDIGO Study Group. Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis. Gastroenterology. 154(4):935-947. 2018
- Ueno A, Jeffery L, Kobayashi T, Hibi T, Ghosh S, Jijon H. Th17 plasticity and its relevance to inflammatory bowel disease. J Autoimmun. 87:38-49. 2018
- Komoto S, Matsuoka K, Kobayashi T, Yokoyama Y, Suzuki Y, Hibi T, Miura S, Hokari R. Safety and efficacy of leukocytapheresis in elderly patients with ulcerative colitis: The impact in steroid-free elderly patients. J Gastroenterol Hepatol. 33(8):1485-1491. 2018
- Matsuoka K, Kobayashi T, Ueno F, Matsui T, Hirai F, Inoue N, Kato J, Kobayashi K, Kobayashi K, Koganei K, Kunisaki R, Motoya S, Nagahori M, Nakase H, Omata F, Saruta M, Watanabe T, Tanaka T, Kanai T, Noguchi Y, Takahashi KI, Watanabe K, Hibi T, Suzuki Y, Watanabe M, Sugano K, Shimosegawa T. Evidence-based clinical practice guidelines for inflammatory bowel disease. J Gastroenterol. 53(3):305-353. 2018
- Matsuoka K, Uemura Y, Kanai T, Kunisaki R, Suzuki Y, Yokoyama K, Yoshimura N, Hibi T. Efficacy of Bifidobacterium breve Fermented Milk in Maintaining Remission of Ulcerative Colitis. Dig Dis Sci. 63(7)1910-1919. 2018
- Park DI, Hisamatsu T, Chen M, Ng SC, Ooi CJ, Wei SC, Banerjee R, Hilmi IN, Jeen YT, Han DS, Kim HJ, Ran Z, Wu K, Qian J, Hu PJ, Matsuoka K, Andoh A, Suzuki Y, Sugano K, Watanabe M, Hibi T, Puri AS, Yang SK. Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 1: risk assessment. Intest Res. 16(1):4-16. 2018
- Park DI, Hisamatsu T, Chen M, Ng SC, Ooi CJ, Wei SC, Banerjee R, Hilmi IN, Jeen YT, Han DS, Kim HJ, Ran Z, Wu K, Qian J, Hu PJ, Matsuoka K, Andoh A, Suzuki Y, Sugano K, Watanabe M, Hibi T, Puri AS, Yang SK. Asian Organization for Crohn's and Colitis and Asia Pacific Association of Gastroenterology consensus on tuberculosis infection in patients with inflammatory bowel disease receiving anti-tumor necrosis factor treatment. Part 2: management. Intest Res. 16(1):17-25. 2018
- Watanabe K, Matsumoto T, Hisamatsu T, Nakase H, Motoya S, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T, for the DIAMOND study group. Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn's Disease. Clinical Gastroenterology and Hepatology. 16(4):542-549. 2018
- Kobayashi T, Hisamatsu T, Suzuki Y, Ogata H, Andoh A, Araki T, Hokari R, Iijima H, Ikeuchi H, Ishiguro Y, Kato S, Kunisaki R, Matsumoto T, Motoya S, Nagahori M, Nakamura S, Nakase H, Tsujikawa T, Sasaki M, Yokoyama K, Yoshimura N, Watanabe K, Katafuchi M, Watanabe M, Hibi T. Predicting outcomes to optimize disease management in inflammatory bowel disease in Japan: their differences and similarities to Western countries. Intest Res. 16(2)168-177. 2018
- Motoya S, Watanabe M, Kim HJ, Kim YH, Han DS, Yuasa H, Tabira J, Isogawa N, Arai S, Kawaguchi I, Hibi T. Tofacitinib induction and maintenance therapy in East Asian patients with active ulcerative colitis: subgroup analyses from three phase 3 multinational studies. Intest Res. 16(2)233-245. 2018
- Ogata H, Yokoyama T, Mizushima S, Hagino A, Hibi T. Comparison of efficacy of once daily multimatrix mesalazine 2.4 g/day and 4.8 g/day with other 5-aminosalicylic acid preparation in active ulcerative colitis: a randomized, double-blind study. Intest Res. 16(2):255-266. 2018
- Okabayashi S, Kobayashi T, Nakano M, Toyonaga T, Ozaki R, Carla Tablante M, Kuronuma S, Takeuchi O, Hibi T. A Simple 1-Day Colon Capsule Endoscopy Procedure Demonstrated to be a Highly Acceptable Monitoring Tool for Ulcerative Colitis. Inflamm Bowel Dis. 24(11):2404-2412. 2018
- Komoto S, Higashiyama M, Watanabe C, Suzuki Y, Watanabe M, Hibi T, Takebayashi T, Asakura K, Nishiwaki Y, Miura S, Hokari R. Clinical differences between elderly-onset ulcerative colitis and non-elderly-onset ulcerative colitis: A nationwide survey data in Japan. J Gastroenterol Hepatol. 33(11):1839-1843. 2018
- Hosoe N, Nakano M, Takeuchi K, Endo Y, Matsuoka K, Abe T, Omori T, Hayashida M, Kobayashi T, Yoshida A, Mizuno S, Yoshihiro N, Naganuma M, Kanai T, Watanabe M, Ueno F, Suzuki Y, Hibi T, Ogata H. Establishment of a Novel Scoring System for Colon Capsule Endoscopy to Assess the Severity of Ulcerative Colitis-Capsule Scoring of Ulcerative Colitis. Inflamm Bowel Dis. 24(12):2641-2647. 2018
- Ozaki R, Kobayashi T, Okabayashi S, Nakano M, Morinaga S, Hara A, Ohbu M, Matsuoka K, Toyonaga T, Saito E, Hisamatsu T, Hibi T. Histological Risk Factors to Predict Clinical Relapse in Ulcerative Colitis with Endoscopically Normal Mucosa. J Crohns Colitis. 12(11):1288-1294. 2018
- Hisamatsu T, Kunisaki R, Nakamura S, Tsujikawa T, Hirai F, Nakase H, Watanabe K, Yokoyama K, Nagahori M, Kanai T, Naganuma M, Michimae H, Andoh A, Yamada A, Yokoyama T, Kamata N, Tanaka S, Suzuki Y, Hibi T, Watanabe M; CERISIER Trial group. Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease with loss of response to infliximab: CERISIER trial. Intest Res. 16(3):494-498. 2018
- Tajiri H, Motoya S, Kinjo F, Maemoto A, Matsumoto T, Sato N, Yamada H, Nagano M, Susuta Y, Ozaki K, Kondo K, Hibi T. Infliximab for pediatric patients with Crohn's disease: A Phase 3, open-label, uncontrolled, multicenter trial in Japan. PLoS One. 13(8):e0201956. 2018
- Motoya S, Watanabe M, Wallace K, Lazar A, Nishimura Y, Ozawa M, Thakkar R, Robinson AM, Singh RSP, Mostafa NM, Suzuki Y, Hibi T. Efficacy and Safety of Dose Escalation to Adalimumab 80 mg Every Other Week in Japanese Patients with Crohn's Disease Who Lost Response to Maintenance Therapy. Inflamm Intest Dis. 2(4):228-235. 2018
- Shinzaki S, Fujii T, Bamba S, Ogawa M, Kobayashi T, Oshita M, Tanaka H, Ozeki K, Takahashi S, Kitamoto H, Kani K, Nanjo S, Sugaya T, Sakakibara Y, Inokuchi T, Kakimoto K, Yamada A, Yasuhara H, Yokoyama Y, Yoshino T, Matsui A, Nakamura M, Tomizawa T, Sakemi R, Kamata N, Hibi T. Seven days triple therapy for eradication of Helicobacter pylori does not alter the disease activity of patients with inflammatory bowel disease. Intest Res. 16(4):609-618. 2018
- Miyoshi J, Matsuoka K, Yoshida A, Naganuma M, Hisamatsu T, Yajima T, Inoue N, Okamoto S, Iwao Y, Ogata H, Ueno F, Hibi T, Kanai T. 5-Aminosalicylic acid aggravates colitis mimicking exacerbation of ulcerative colitis. Intest Res. 16(4):635-640. 2018
- Sagami S, Kobayashi T, Hibi T. Prevention of Infectious Diseases due to Immunosuppression and Vaccinations in Asian Patients with Inflammatory Bowel Disease. Inflamm Intest Dis. 3(1):1-10. 2018
- Okabayashi S, Kobayashi T, Hibi T. Drug Lag for Inflammatory Bowel Disease Treatments in the East and West. Inflamm Intest Dis. 3(1):25-31. 2018
- Imaeda H, Hibi T. The Burden of Diverticular Disease and Its Complications: West versus East. Inflamm Intest Dis. 3(2):61-68. 2018
- Matsuoka K, Kobayashi T, Ueno F, Matsui T, Hirai F, Inoue N, Kato J, Kobayashi K, Kobayashi K, Koganei K, Kunisaki R, Motoya S, Nagahori M, Nakase H, Omata F, Saruta M, Watanabe T, Tanaka T, Kanai T, Noguchi Y, Takahashi KI, Watanabe K, Hibi T, Suzuki Y, Watanabe M, Sugano K, Shimosegawa T. Evidence-based clinical practice guidelines for inflammatory bowel disease. J Gastroenterol. 53(3):305-353. 2018
- Hisamatsu T, Kunisaki R, Nakamura S, Tsujikawa T, Hirai F, Nakase H, Watanabe K, Yokoyama K, Nagahori M, Kanai T, Naganuma M, Michimae H, Andoh A, Yamada A, Yokoyama T, Kamata N, Tanaka S, Suzuki Y, Hibi T, Watanabe M; CERISIER Trial group. Effect of elemental diet combined with infliximab dose escalation in patients with Crohn's disease with loss of response to infliximab: CERISIER trial. Intestinal Research 16(3):494-498. 2018
- Kobayashi T, Hishida A, Tanaka H, Nuki Y, Bamba S, Yamada A, Fujii T, Shinzaki S, Yokoyama Y, Yoshida A, Ozeki K, Ashizuka S, Kamata N, Nanjo S, Kakimoto K, Nakamura M, Matsui A, Yamauchi R, Takahashi S, Tomizawa T, Yoshino T, Hibi T. Real-world Experience of Anti-tumor Necrosis Factor Therapy for Internal Fistulas in Crohn's Disease: A Retrospective Multicenter Cohort Study. Inflamm Bowel Dis 23(12):2245-2251. 2017
- Hibi T, Imai Y, Murata Y, Matsushima N, Zheng R, Gasink C. Efficacy and safety of ustekinumab in Japanese patients with moderately to severely active Crohn's disease: a subpopulation analysis of phase 3 induction and maintenance studies. Intest Res. 15(4):475-486. 2017
- Hirai F, Andoh A, Ueno F, Watanabe K, Ohmiya N, Nakase H, Kato S, Esaki M, Endo Y, Yamamoto H, Matsui T, Iida M, Hibi T, Watanabe M, Suzuki Y, Matsumoto T. Efficacy of endoscopic balloon dilation for small bowel strictures in patients with Crohn's disease: A nationwide, multi-center, open-label, prospective cohort study. J Crohns Colitis. 12(4):394-401. 2017
- Yokoyama T, Ohta A, Motoya S, Takazoe M, Yajima T, Date M, Nii Masahiro, Nagy P, Suzuki Y, Hibi T. Efficacy and Safety of Oral Budesonide in Patients with Active Crohn's Disease in Japan: A Multicenter, Double-Blind, Randomized, Parallel-Group Phase 3 Study. Inflammatory Intestinal Diseases 2(3)154-162. 2017
- Hibi T, Panaccione R, Katafuchi M, Yokoyama K, Watanabe K, Matsui T, Matsumoto T, Travis S, Suzuki Y. The 5C Concept and 5S Principles in Inflammatory Bowel Disease Management.J Crohns Colitis. 11(11): 1302-1308 2017
- Toyonaga T, Kobayashi T, Nakano M, Saito E, Umeda S, Okabayashi S, Ozaki R, Hibi T. Usefulness of fecal calprotectin for the early prediction of short-term outcomes of remission-induction treatments in ulcerative colitis in comparison with two-item patient-reported outcome. PLoS One 21;12(9) :e0185131 2017
- Nakase H, Motoya S, Matsumoto T, Watanabe K, Hisamatsu T, Yoshimura N, Ishida T, Kato S, Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, Hibi T; DIAMOND study group.Significance of measurement of serum trough level and anti-drug antibody of adalimumab as personalised pharmacokinetics in patients with Crohn's disease: a subanalysis of the DIAMOND trial.Aliment Pharmacol Ther. 46(9):873-882 2017
- Inoue N, Kobayashi K, Naganuma M, Hirai F, Ozawa M, Arikan D, Huang B, Robinson AM, Thakkar RB, and Hibi T: Long-term safety and efficacy of adalimumab for intestinal Behçet's disease in the open label study following a phase 3 clinical trial. Intest Res. 15(3):395-401 2017
- Ogata H, Aoyama N, Mizushima S, Hagino A, and Hibi T: Comparison of efficacy of multimatrix mesalazine 4.8 g/day once-daily with other high-dose mesalazine in active ulcerative colitis: a randomized, double-blind study.Intest Res 15(3):368-379 2017
- Ogata H, Ohori A, Nishino H, Mizushima S, Hagino A, and Hibi T: Comparison of efficacies of once-daily dose multimatrix mesalazine and multiple-dose mesalazine for the maintenance of remission in ulcerative colitis: a randomized, double-blind study.Intest Res 15(3):358-367 2017
- Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Hida S, Okada Y, Kurihara C, Ebinuma H, Nakamoto N, Saito H, Hibi T, Miura S, Hokari R, and Kanai T: Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling. J Hepatol. 67(4):780-790 2017
- Suzuki Y, Motoya S, Hanai H, Hibi T, Nakamura S, Lazar A, Robinson AM, Skup M, Mostafa NM, Huang B, Thakkar R, Watanabe M: Erratum to: Four-year maintenance treatment with adalimumab in Japanese patients with moderately to severely active ulcerative colitis. J Gastroenterol 52(9):1079. 2017
- Nagahori M, Kochi S, Hanai H, Yamamoto T, Nakamura S, Omuro S, Watanabe M, Hibi T; OPTIMUM Study Group : Real life results in using 5-ASA for maintaining mild to moderate UC patients in Japan, a multi-center study, OPTIMUM Study.BMC Gastroenterol. 17(1):47 2017
- Suzuki Y, Iida M, Ito H, Nishino H, Ohmori T, Arai T, Yokoyama T, Okubo T, Hibi T : 2.4 g Mesalamine (Asacol 400 mg tablet) Once Daily is as Effective as Three Times Daily in Maintenance of Remission in Ulcerative Colitis: A Randomized, Noninferiority, Multi-center Trial : Inflamm Bowel Dis 23(5):822-832 2017
- Hibi T, Imai Y, Senoo A, Ohta K, Ukyo Y : Efficacy and safety of golimumab 52-week maintenance therapy in Japanese patients with moderate to severely active ulcerative colitis: a phase 3, double-blind, randomized, placebo-controlled study-(PURSUIT-J study).J Gastroenterol. 52(10):1101-1111 2017
- Suzuki Y, Motoya S, Hanai H, Hibi T, Nakamura S, Lazar A, Robinson AM, Skup M, Mostafa NM, Huang B, Thakkar R, Watanabe M : Four-year maintenance treatment with adalimumab in Japanese patients with moderately to severely active ulcerative colitis.J Gastroenterol 52:1031–1040 2017
- Umeda S, Serizawa H, Kobayashi T, Toyonaga T, Saito E, Nakano M, Higuchi H, Tsunematsu S, Watanabe N, Hibi T, Morinaga S: Clinical significance of human intestinal spirochetosis: a retrospective study.Nihon Shokakibyo Gakkai Zasshi 114(2):230-237 2017
- Okabayashi S, Kobayashi T [corresponding author], Sujino T, Ozaki R, Umeda S, Toyonaga T, Saito E, Nakano M, Tablante MC, Morinaga S, and Hibi T: Steroid-refractory extensive enteritis complicated with ulcerative colitis successfully treated with adalimumab. Intest Res 15(4):535-539 2017
- Shimizu S, Kobayashi T, Tomioka H, Ohtsu K, Matsui T, Hibi T: Involvement of herbal medicine as a cause of mesenteric phlebosclerosis: results from a large-scale nationwide survey.J Gastroenterol 52(3):308-314 2017
- Shinzaki S, Matsuoka K, Iijima H, Mizuno S, Serada S, Fujimoto M, Arai N, Koyama N, Morii E, Watanabe M, Hibi T, Kanai T, Takehara T, Naka T:Leucine-rich Alpha-2 Glycoprotein is a Serum Biomarker of Mucosal Healing in Ulcerative Colitis.J Crohns Colitis 11(1) : 84-91 2017
- Ueno F, Nakayama Y, Hagiwara E, Kurimoto S, and Hibi T: Impact of Inflammatory bowel disease on Japanese patients' quality of life:results of a patient questionnaire survey. J Gastroenterol 52(5):555-567 2017
- Matsumoto T, Motoya S, Watanabe K, Hisamatsu T, Nakase H, Yoshimura N, Ishida T, Kato S,Nakagawa T, Esaki M, Nagahori M, Matsui T, Naito Y, Kanai T, Suzuki Y, Nojima M, Watanabe M, and Hibi T; Diamond Study Group :Adalimumab monotherapy and a combination with azathioprine for Crohn's disease:A prospective,randomized trial.J Crohns Colitis 10(11):1259-1266 2016
- Toyonaga T, Matsuura M, Mori K, Honzawa Y, Minami N, Yamada S, Kobayashi T, Hibi T, and Nakase H : Lipocalin 2 prevents intestinal inflammation by enhancing phagocytic bacterial clearance in macrophages.Sci Rep.13;6:35014 2016
- Watanabe T, Ajioka Y, Mitsuyama K, Watanabe K, Hanai H, Nakase H, Kunisaki R, Matsuda K, Iwakiri R, Hida N, Tanaka S, Takeuchi Y, Ohtsuka K, Murakami K, Kobayashi K, Iwao Y, Nagahori M, Iizuka B, Hata K, Igarashi M, Hirata I, Kudo SE, Matsumoto T, Ueno F, Watanabe G, Ikegami M, Ito Y, Oba K, Inoue E, Tomotsugu N, Takebayashi T, Sugihara K, Suziki Y, Watanabe M, and Hibi T: Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-associated Colorectal Cancer.Gastroenterology 151(6):1122-1130 2016
- Ogata H, Watanabe M, Matsui T, Hase H, Okayasu M, Tsuchiya T, Shinmura Y, and Hibi T: Safety of adalimumab and predictors of adverse events in 1693 Japanese patients with Crohn's disease.J Crohns Colitis 10(9):1033-41 2016
- Naganuma M, Aoyama N, Suzuki Y, Nishino H, Kobayashi K, Hirai F, Watanabe K, and Hibi T: Twice-daily Budesonide 2-mg Foam Induces Complete Mucosal Healing in Patients with Distal Ulcerative Colitis. 2016
- Kobayashi T, Umeno J, Hisamatsu T, Esaki M, Matsui T, Matsumoto T, and Hibi T: Chronic nonspecific multiple ulcers of the small intestine (CNSU) and chronic enteropathy associated with SLCO2A1 (CEAS). Nihon Shokakibyo Gakkai Zasshi 113(8):1380-5 2016
- Kobayashi T, Suzuki Y, Motoya S, Hirai F, Ogata H, Ito H, Sato N, Osaki K, Watanabe M, and Hibi T: First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitis—results from a multicenter prospective randomized controlled trial and its post-hoc analysis. J Gastroenterol 51(3):241-51 2016
- Sawada K, Ohdo M, Ino T, Nakamura T, Numata T, Shibata H, Sakou J, Kusada M, and Hibi T: Safety and Tolerability of Nafamostat Mesilate and Heparin as Anticoagulants in Leukocytapheresis for Ulcerative Colitis: Post Hoc Analysis of a Large-Scale, Prospective, Observational Study. Ther Apher Dial 20(2):197-204 2016
- Imaeda H, Nakajima K, Hosoe N, Nakahara M, Zushi S, Kato M, Kashiwagi K, Matsumoto Y, Kimura K, Nakamura R, Wada N, Tsujii M, Yahagi N, Hibi T, Kanai T, Takehara T, and Ogata H: Percutaneous endoscopic gastrostomy under steady pressure automatically controlled endoscopy:First clinical series. World J Gastrointest Endosc 10;8(3):186-91 2016
- Suzuki Y, Iida M, Ito H, Tachikawa N, and Hibi T: Investigation of a High-Dose pH-Dependent-Release Mesalazine on the Induction of Remission in Active Crohn's Disease. Drugs R D 16(1):35-43 2016
- Suzuki Y, Iida M, Ito H, Saida I, and Hibi T: Efficacy and safety of two pH-dependent-release mesalamine doses in moderately active ulcerative colitis: a multicenter, randomized, double-blind, parallel-group study. Intest Res 14(1):50-9 2016
- Togawa K, Matsuzaki J, Kobayakawa M, Fukushima Y, Suzaki F, Kasugai K, Nishizawa T, Naito Y, Hayakawa T, Kamiya T, Andoh T, Yoshida H, Tokura Y, Nagata H, Mori M, Kato K, Hosoda H, Takebayashi T, Miura S, Uemura N, Joh T, Hibi T, and Suzuki H: Association of baseline plasma des-acyl ghrelin level with the response to rikkunshito in patients with functional dyspepsia. J Gastroenterol Hepatol 31(2):334-41, 2016
- Ooi CJ, Makharia GK, Hilmi I, Gibson PR, Fock KM, Ahuja V, Ling KL, Lim WC, Thia KT, Wei SC, Leung WK, Koh PK, Gearry RB, Goh KL, Ouyang Q, Sollano J, Manatsathit S, de Silva HJ, Rerknimitr R, Pisespongsa P, Abu Hassan MR, Sung J, Hibi T, Boey CC, Moran N, Leong RW; Asia Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease: Asia Pacific Consensus Statements on Crohn’n disease Part2: Management. J Gastroenterol Hepatol 31(1):56-68 2016
- Ooi CJ, Makharia GK, Hilmi I, Gibson PR, Fock KM, Ahuja V, Ling KL, Lim WC, Thia KT, Wei SC, Leung WK, Koh PK, Gearry RB, Goh KL, Ouyang Q, Sollano J, Manatsathit S, de Silva HJ, Rerknimitr R, Pisespongsa P, Abu Hassan MR, Sung J, Hibi T, Boey CC, Moran N, Leong RW; Asia Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease: Asia Pacific Consensus Statements on Crohn’n disease. Part1: Definition,diagnosis and epidemiology.(Asia Pacific Crohn’n Disease Consensus—Part 1). J Gastroenterol Hepatol 31(1):45-55 2016
- Hibi T, Hirohata S, Kikuchi H, Tateishi U, Sato N, Ozaki K, Kondo K, Ishigatsubo Y: Infliximab therapy for intestinal,neurological,and vascular involvement in Behcet disease:Efficacy,safety,and pharmacokinetics in a multicenter,prospective,open-label,single-arm phase 3 study.Medicine(Baltimore) 95:(24)e3863 2016
- Hosoe N, Matsukawa S, Kanno Y, Naganuma M, Imaeda H, Ida Y, Tsuchiya Y, Hibi T, Ogata H,and Kanai T: Cross-sectional small intestinal surveillance of maintenance hemodialysis patients using video capcule endoscopy:SCHEMA study.Endosc Int Open4(5):E589-96 2016
- Komoto S, Motoya S, Nishiwaki Y, Matsui T, Kunisaki R, Matsuoka K, Yoshimura N, Kagaya T, Naganuma M, Hida N, Watanabe M, Hibi T, Suzuki Y, Miura S, Hokari R ; Japanese study group for pregnant woman with IBD: Pregnancy outcome in woman with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy:a multicenter study from Japan.Intest ResApr;14(2):139-45 2016
- Watanabe C, Komoto S, Tomita K, Hokari R, Tanaka M, Hirata I, Hibi T, Kaunitz JD, Miura S: Endoscopic and clinical evalution of treatment and prognosis of Cronkhite-Canada Syndrome:a Japanese nationwide survey.J Gastroenterol Apr;51(4):327-36 2016
- Wada Y, Hisamatsu T, Naganuma M, Matsuoka K, Okamoto S, Inoue N, Yajima T, Kouyama K, Iwao Y, Ogata H, Hibi T, Abe T,and Kanai T:Risk factors for decreased bone mineral density in inflammatory bowel disease:A cross-sectional study.Clin Nutr Dec;34(6):1202-9 2015
- Yoshimura N, Watanabe M, Motoya S, Tominaga K, Matsuoka K, Iwakiri R, Watanabe K, Hibi T;AJM300 Study Group:Safety and Efficacy of AJM300,an Oral Antagonist of α4 Integrin,in Induction Therapy for Patients with Active Ulcerative Colitis.Gastroenterology Dec;149(7):1775-1783 2015
- Umeno J, Hisamatsu T, Esaki M, Hirano A, Kubokura N, Asano K, Kochi S, Yanai S, Fuyuno Y, Shimamura K, Hosoe N, Ogata H, Watanabe T, Aoyagi K, Ooi H, Watanabe K, Yasukawa S, Hirai F, Matsui T, Iida M, Yao T, Hibi T, Kosaki K, Kanai T, Kitazono T, Matsumoto T.A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene,Encoding a Prostaglandin Transporter.PLoS Genet Nov 5;11(11) 2015
- Yoshimura N, Yokoyama Y, Matsuoka K, Takahashi H, Iwakiri R, Yamamoto T, Nakagawa T, Fukuchi T, Motoya S, Kunisaki R, Kato S, Hirai F, Ishiguro Y, Tanida S, Hiraoka S, Mitsuyama K, Ishihara S, Tanaka S, Otaka M, Osada T, Kagaya T, Suzuki Y, Nakase H, Hanai H, Watanabe K, Kashiwagi N, Hibi T.An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn's disease.BMC Gastroenterol Nov 19;15:163 2015
- Hisamatsu T, Ono N, Imaizumi A, Mori M, Suzuki H, Uo M, Hashimoto M, Naganuma M, Matsuoka K, Mizuno S, Kitazume MT, Yajima T, Ogata H, Iwao Y, Hibi T, Kanai T..Decreased Plasma Histidine Level Predicts Risk of Relapse in Patients with Ulcerative Colitis in Remission.PLoS One Oct 16;10(10) 2015
- Suzuki Y, Matsui T, Ito H, Ashida T, Nakamura S, Motoya S, Matsumoto T, Sato N, Ozaki K, Watanabe M, Hibi T. Circulating Interleukin 6 and Albumin,and Infliximab Levels Are Good Predictors of Recovering Efficacy After Dose Escalation Infliximab Therapy in Patients with Loss of Response to Treatment for Crohn’s Disease:A Prospective Clinical Trial Inflamm Bowel Dis. Sep;21(9):2114-22 2015
- Kawa S, Okazaki K, Notohara K, Watanabe M, Shimosegawa T ; Study Group for Pancreatitis Complicated with Inflammatory Bowel Disease organized by The Research Committee for Intractable Pancreatic Disease(Chairman:Tooru Shimosegawa)and The Research Committee for Intractable Inflammatory Bowel Disease(Chairman:Mamoru Watanabe),both of which are supported by the Ministry of Health,Labour,and welfare of Japan.Autoimmune pancreatitis Complicated with inflammatory bowel disease and comparative study of type 1 and type 2 autoimmune pancreatitis. 2015
- Takayama T, Okamoto S, Hisamatsu T, Naganuma M, Matsuoka K, Mizuno S,Bessho R, Hibi T, Kanai T. Computer-Aided Prediction of Long-Term Prognosis of Patients with Ulcerative Cclitis after Cytoapheresis Therapy.PLoS One Jun 25;10(6):e0131197 2015
- Chu PS, Ebinuma H, Nakamoto N, sugiyama K, Usui S, Wakayama Y, Taniki N, Yamaguchi A, Shiba S,Yamagishi Y, Wakita T, Hibi T, Saito H, Kanai T, Genotype-Associated Differential NKG2D Expression on CD56+CD3+ Lymphocytes Predicts Response to Pegylated-lnterferon/Ribavirin Therapy in Chronic Hepatitis C.PLoS One May;10(5):e0125664. 2015
- Tanida S, Inoue N, Kobayashi K, Naganuma M, Hirai F, Iizuka B, Watanabe K, Mitsuyama K, Inoue T,Ishigatsubo Y, Suzuki Y, Nagahori M, Motoya S, Nakamura S, Arora V, Robinson AM, Thakkar Rb, Hibi T.Adalimumab for the Treatment of Japanese Patients With Intestinal Behcet`s Disease.Clin Gastroenterol Hepatol May;13(5):940-8 2015
- Sato H, Tomita K, Yasue C, Umeda R, Ebinuma H, Ogata S, Du W, Soga S, Maruta K, Yasutake Y, Narimatsu K, Usui S, Watanabe C, Komoto S, Teratani T, Suzuki T, Yokoyama H, Saito H, Nagao S, Hibi T, Miura S, Kanai T, and Hokari R:Pregnant woman with non-comatose autoimmune acute liver failure in the second trimester rescued using medical therapy:A case report.Hepatol Res Mar;45(3):349-55 2015
- Sakuraba A, Okamoto S, Matsuoka K, Sato T, Naganuma M, Hisamatsu T, Iwao Y, Ogata H, Kanai T, and Hibi T:Combination therapy with infliximab and thiopurine compared to infliximab monotherapy in maintaining remission of postoperative Crohn’s disease.Digestion 91(3):233-8 2015
- Oryoji D, Hisamatsu T, Tsuchiya K, Umeno J, Ueda S, Yamamoto K, Matsumoto T, Watanabe M, Hibi T, and Sasazuki T. Associations of HLA class I alleles in Japanese patients with Crohn's disease.Genes Immun Jan-Feb;16(1):54-6 2015
- Yokoyama Y*, Matsuoka K*, Kobayashi T*[*First authorship shared], Sawada K, Fujiyoshi T, Ando T, Ohnishi Y, Ishida T, Oka M, Yamada M, Nakamura T, Ino T, Numata T, Aoki H, Sakou J, Kusada M, Maekawa T, Hibi T. A large-scale, prospective, observational study of leukocytapheresis for ulcerative colitis: Treatment outcomes of 847 patients in clinical practice. J Crohn Colitis Sep 8(9):981-991 2014
- Steinbach EC, Kobayashi T, Russo SM, Sheikh SZ, Gipson G, Kennedy S, Uno JK, Mishima Y, Borst LB, Liu B, Herfarth H, Ting J, Sartor RB, Plevy SE. Innate PI3K p110δ regu lates Th1/Th17 development and microbiota-dependent colitis. J Immunol Apr 192(8):3958-68 2014
- Suzuki Y, Motoya S, Hanai H, Hibi T, Anne M.Robinson, Nael M. Mostafa, Jingdong Chao, Vipin Arora, Anne Camez, Roopal B, Thakkar, Watanabe M. Efficacy and safety of adalimumab in Japanese patients with moderately to severely active ulcerative colitis.
J Gastroenterol 49:283-294 Feb 2014.
- Takabayashi K, Kashiwagi K, Kawata T, Hibi T, Ogata H, Yahagi N, Kitagawa Y, Shigematsu N, Kanai T. Continuous low-dose irradiation by l-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin.
Cancer Biol Ther 15(1):81-8 Jan 2014.
- Esaki M, Matsumoto T, Watanabe K, Hibi T, Matsumoto T, Nouda S, Higuchi K, Ohmiya N, Goto H, Kurokawa S, Motoya S, Watanabe M. Use of capsule endoscopy in patients with Crohn's disease in Japan: a multicenter survey. J Gastroenterol Hepatol 29(1):96-101 Jan 2014.
- Mikami Y, Mizuno S, Nakamoto N, Hibi T, Yoshimura A, Kanai T. :Macrophages and Dendritic Cells Emerge in the Liver during Intestinal Inflammation and Predispose the Liver to Inflammation. PLoS One 9(1):e84619 Jan 2014.
- Nakamura S, Yaguchi T, Kawamura N, Hibi T, Kawakami Y. :TGF-β1 in Tumor Microenvironments Induces Immunosuppression in the Tumors and Sentinel Lymph Nodes and Promotes Tumor Progression. J Immunother Feb 37(2):63-72 2014
- Hibi T, Sakuraba A, Watanabe M, : C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn's disease. J Gastroenterol,49(2):254-62 Feb 2014
- Sandborn WJ, Feagan BG, Marano C, Rutgeerts P, Zhang H, Strauss R, Johanns J, Adedokun OJ, Guzzo C, Colombel JF, Reinisch W, Gibson PR, Collins J, Jarnerot G, Hibi T; PURSUIT-SC Study Group: Subcutaneous Golimumab Induces Clinical Response and Remission in Patients With Moderate to Severe Ulcerative Colitis. Gastroenterology 146(1):85-95 , 2014
- Tomita K, Teratani T, Suzuki T, Hibi T. Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. Hepatology 59(1):154-69 , 2014
- Hisamatsu T, Ueno F, Matsumoto T, Hibi T.
The 2nd edition of consensus statements for the diagnosis and management of intestinal Behcet's disease: indication of anti-TNFα monoclonal antibodies. J Gastroenterol 49(1):156-62 Jan 2014
- Akagi H, Higuchi H, Sumimoto H, Hibi T. Suppression of myeloid cell leukemia-1(Mcl-1)enhances chemotherapy-associated apoptosis in gastric cancer cells. Gastric Cancer 16(1):100-10 2013
- Takayama T, Kanai T, Matsuoka K, Hibi T. Long-term prognosis of patients with ulcerative colitis treated with cytapheresis therapy. J Crohns Colitis 7(2):e49-54 2013
- Sujino T, Ebinuma H, Hosoe N, Hibi T. Epstein-barr virus-associated gastritis: a case report. Dig Dis Sci 58(3):883-6 2013
- Uo M, Hisamatsu T, Miyoshi J, Hibi T. Mucosal CXCR4+lgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcyR-mediated CD14 macrophage activation.Gut 62(12):1734-44 2013
- Kawakami A, Tanaka M, Nishigaki M, Hibi T, Sanada H, Yamamoto-Mitani N, Kazuma K. :Relationship between non-adherence to aminosalicylate medication and the risk of clinical relapse among Japanese patients with ulcerative colitis in clinical remission: a prospective cohort study. J Gastroenterol 48(9):1006-15 2013
- Mizuno S, Yamagishi Y, Ebinuma H, Hibi T.
Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier. Clin J Gastroenterol 6(2):188-192 2013
- Matsuzaki J, Suzuki H, Tsugawa H, Hibi T.
Bile acids increase levels of microRNAs221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis. Gastroenterology 145(6):1300-11 2013
- Hirata T, Tomita K, Kawai T, Hibi T.
Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study(FANTASY). Int J Endocrinol 2013:587140 2013
- Nishizawa T, Suzuki H, Takahashi M, Hibi T.
Effect of ursodeoxycholic acid and endoscopic sphincterotomy in long-term stenting for common bile duct stones. J Gastroenterol Hepatol 28(1);63-7 2013
- Hirata K, Suzuki H, Matsuzaki J, Hibi T.
Improvement of reflux symptom related quality of life after Helicobacter pylori eradication therapy. J Clin Biochem Nutr 52(2);172-8 2013
- Mogami S, Suzuki H, Tsugawa H, Hibi T.
Impaired heme oxygenase-1 induction in the gastric antrum induces disruption of the interstitial cells of Cajal network in a rat model of streptozotocin-induced diabetes. Neurogastroenterol Motil 25(7);609-e465 2013
- Kishikawa H, Nishida J, Takarabe S, Hibi T.
"Circular reddish lesions": a possibly characteristic endoscopic finding in Henoch-Schonlein purpura. Endoscopy Suppl 2 E33-4 2013
- Mizuno S, Yamagishi Y, Ebinuma H, Hibi T.
Progressive liver failure induced by everolimus for renal cell carcinoma in a 58-year-old male hepatitis B virus carrier. Clim J Gastroenterol 6(2);188-192 2013
- Koike S, Sujino T, Ohmori H, Hibi T, Ono T. Gastric emptying rate in subjects with malocclusion examined by [13C] breath test.
J Oral Rehabil 40(8);574-581 2013
- Nishizawa T, Suzuki H, Takahashi M, Hibi T.
Delay of second-line eradication therapy for H. pylori can increase eradication failure.
J Gastroenterol Hepatol 28(10):1608-10 2013
- Liu DY, Pan CS, Liu YY, Hibi T, Liu HN, Han JY
Huang Qi Jian Zhong Pellet Attenuates TNBS-Induced Colitis in Rats via Mechanisms Involving Improvement of Energy Metabolism. Evid Based Complement Alternat Med vol.2013:1-14 2013
- Watanabe M, Nishino H, Sameshima Y, Hibi T. Randomised clinical trial: evaluation of the efficacy of mesalazine (mesalamine) suppositories in patients with ulcerative colitis and active rectal inflammation - a placebo-controlled study
Alimentary Pharmacology Ther 38(3);264-73 2013
- Suzuki Y, Motoya S, Takazoe M, Hibi T. Efficacy and tolerability of oral budesonide in Japanese patients with active Crohn's disease: A multicentre, double-blind, randomized, parallel-group Phase Ⅱstudy J Crohns Colitis 7(3):239-247 2013
- Hirano Y, Takeuchi H, Oyama T, Hibi T, Kitagawa T. Minimally invasive surgery for esophageal epiphrenic diverticulum: the results of 133 patients in 25 published series and our experience Surg Today 43(1):1-7 2013
- Matsumoto A, Kanai T, Mikami Y, Hibi T. IL-22-producing RORγt-dependent innate lymphoid cells play a novel protective role in murine acute hepatitis. PLoS One 8(4):e62853 2013
- Miyoshi J, Matsuoka K, Inoue N, Hibi T. Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients. J Crohns Colitis 7(12):e609-14 2013
- Miyake M, Toguchi H, Nishibayashi T, Hibi T. Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues. J Pharm Sci 102(8):2564-71 2013
- Hayashi A, Sato T, Kamada N, Hibi T, Roers A, Yagita H, Ohteki T, Yoshimura A, Kanai T.: A Single Strain of Clostridium butyricum Induces Intestinal IL-10-Producing Macrophages to Suppress Acute Experimental Colitis in Mice. Cell Host Microbe 13(6):711-22 2013
- Hirata K, Suzuki H, Imaeda H, Hibi T. CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence.
Br J Cancer 109(2):379-86 , 2013
- Funakoshi S, Hashiguchi A, Teramoto K, Hibi T. Second-line chemotherapy for refractory small cell neuroendocrine carcinoma of the esophagus that relapsed after complete remission with irinotecan plus cisplatin therapy: Case report and review of the literature. Oncol Lett 5(1):117-122 2013
- Takahashi T, Suzuki H, Imai T, Hibi T. Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain-containing m-Numb protein expression in regenerating gastric mucosa. PLoS One 8(1):e53540 2013
- Handa T, Kanai T, Sato T, Hibi T: Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice. Immunol Lett 150(1-2):123-9 2013
- Nakamura Y, Kanai T, Saeki K,and Hibi T: CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion. Am J Physiol Gastrointest Liver Physiol 304(8):G700-7, 2013
- Chu PS, Nakamoto N, Ebinuma H,and Hibi T: C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice. Hepatology 58(1):337-50, 2013
- Hosoe N, Matsuoka K, Naganuma M,and Hibi T: Applicability of second-generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study. J Gastroenterol Hepatol 28(7):1174-9, 2013
- Sato A, Saito Y, Sugiyama K, Hibi T,and Saito H: Suppressive Effect of the Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid (SAHA), on Hepatitis C Virus Replication via Epigenetic Changes in Host Cells. J Cell Biochem 114(9):1987-96, 2013
- Yoneno K, Hisamatsu T, Shimamura K,and Hibi T: TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. Immunology 139(1):19-29, 2013
- Ueno F, Matsui T, Matsumoto T,and Hibi T: Guidelines Project Group of the Research Group of Intractable Inflammatory Bowel Disease subsidized by the Ministry of Health, Labour and Welfare of Japan and the Guidelines Committee of the Japanese Society of Gastroenterology.: Evidence-based clinical practice guidelines for Crohn's disease, integrated with formal consensus of experts in Japan. J Gastroenterol 48(1):31-72, 2013
- Hisamatsu T, Kanai T, Mikami Y,and Hibi T: Immune aspects of the pathogenesis of inflammatory bowel disease. Pharmacol Ther 137(3):283-97, 2013
- Chang J, Hisamatsu T, Shimamura K,and Hibi T: Activated hepatic stellate cells mediate the differentiation of macrophages. Hepatol Res 43(6):658-69, 2013
- Kabashima-Niibe A, Higuchi H, Takaishi H,and Hibi T: Mesenchymal stem cells regulate epithelial-mesenchymal transition and tumor progression of pancreatic cancer cells. Cancer Sci 104(2):157-64, 2013
- Suzuki Y, Motoya S, Takazoe M,and Hibi T: Efficacy and tolerability of oral budesonide in Japanese patients with active Crohn's disease: a multicentre, double-blind, randomized, parallel-group Phase II study. J Crohns Colitis 7(3):239-47, 2013
- Nakashita M, Suzuki H, Miura S,and Hibi T: Attenuation of acetic acid-induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors.
Dig Dis Sci 58(2):354-62, 2013
- Saito Y, Suzuki H, Imaeda H,and Hibi T: The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells . Int J Cancer 132(8):1751-60, 2013
- Kobayashi T, Russo SM, Steinbach EC, Russo SM, Matsuoka K, Nochi T, Maharshak N, Borst LB, Hostager B, Garcia-Martinez JV, Rothman PB, Kashiwada M, Sheikh SZ, Murray PJ,and Plevy SE: NFIL3 deficient mice develop microbiota dependent, IL-12/23 driven spontaneous colitis. J Immunol 15;192(4):1918-27, 2014
- Matsuzaki J, Suzuki H, Okuda S,and Hibi T: Biliary findings assist in predicting enlargement of intraductal papillary mucinous neoplasms of the pancreas. Clin Gastroenterol Hepatol 11(5):548-54, 2013
- Onyiah JC, Sheikh SZ, Maharshak N, Kobayashi T, Mackey LC, Hansen JJ, Moeser AJ, Rawls JF, Borst LB, Otterbein LE,and Plevy SE: Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. Gastroenterology 144(4):789-98, 2013
英文総説・著書
- K Tominaga, T Tanaka, M Kanazawa, S Watanabe, R Nemoto, K Abe, A Kanamori, A Yamamiya, K Goda, Y Kushima, K Chibana, T Masawa, T Fukuda, T Hibi and A Irisawa. A Case of Crohn’s Disease with Cardiac Tamponade Caused by Tuberculous Pericarditis: Assessment of a Rare Phenomenon. Healthcare Jun 9;9(6):695. 2021
- Toyonaga T, Kobayashi T, Kuronuma S, Ueno A, Kiyohara H, Okabayashi S, Takeuchi O, Redfern CPF, Terai H, Ozaki R, Sagami S, Nakano M, Coulthard SA, Tanaka Y, Hibi T. Increased DNA-incorporated thiopurine metabolite as a possible mechanism for leukocytopenia through cell apoptosis in inflammatory bowel disease patients with NUDT15 mutation. J Gastroenterol Sep 4. doi: 10.1007/s00535-021-01820-0. Online ahead of print. 2021
- Sagami S, Kobayashi T, Aihara K, Umeda M, Morikubo H, Matsubayashi M, Kiyohara H, Nakano M, Ohbu M, Hibi T. Transperineal Ultrasound Predicts Endoscopic and Histological Healing in Ulcerative Colitis. Aliment Pharmacol Ther Jun;51(12):1373-1383. 2020
- Okabayashi S, Kobayashi T, Hibi T. Inflammatory Bowel Disease in Japan-Is It Similar to or Different from Westerns?- J Anus Rectum Colon. Jan 30;4(1):1-13. 2020
- Ben-Horin S, Zhao Y, Guo J, Mao R, Novack L, Sergienko R, Zhang J, Kobayashi T, Hibi T, Chowers Y, Colombel JF, Peyrin-Biroulet L, Kaplan G, Chen MH. Efficacy of biological drugs in short-duration versus long-duration inflammatory bowel disease: a protocol for a systematic review and an individual-patient level meta-analysis of randomised controlled trials. BMJ Open. 9(1):e024222. 2019
- Yagisawa K, Kobayashi T, Ozaki R, Okabayashi S, Toyonaga T, Miura M, Hayashida M, Saito E, Nakano M, Matsubara H, Hisamatsu T, Hibi T. Randomized, crossover questionnaire survey of acceptabilities of controlled-release mesalazine tablets and granules in ulcerative colitis patients. Intest Res. 17(1):87-93. 2019
- Kobayashi T, Hisamatsu T, Suzuki Y, Ogata H, Andoh A, Araki T, Hokari R, Iijima H, Ikeuchi H, Ishiguro Y, Kato S, Kunisaki R, Matsumoto T, Motoya S, Nagahori M, Nakamura S, Nakase H, Tsujikawa T, Sasaki M, Yokoyama K, Yoshimura N, Watanabe K, Katafuchi M, Watanabe M, Hibi T. Predicting outcomes to optimize disease management in inflammatory bowel diseases in Japan:their differences and similarities to Western countries. Intestinal Research. 16(2):168-177. 2018
- Hibi T, Hisamatsu T, Kobayashi T. Advances in Endoscopy in Inflammatory Bowel Disease. Springer Japan 2017
- Hibi T. A new start for 'Intestinal Research' as an official journal of AOCC.Intest Res Jan;14(1):1 2016
- Kobayashi T and Hibi T. Ulcerative colitis: Which makes patients happier, surgery or anti-TNF? Nat Rev Gastroenterol Hepatol May 2014 in press.
- Hosoe N, Ogata H, Hibi T. Endoscopic imaging of parasites in the human digestive tract.
Parasitol Int 63(1):216-20 Feb 2014
- Matsuoka K, Hibi T. Treatment guidelines in inflammatory bowel disease: the Japanese perspectives. Dig Dis 31(3-4):363-7 Nov 2013
- Naganuma M, Sakuraba A, Hibi T. Ulcerative colitis; prevention of relapse. Expert Rev Gastroenterol Hepatol 7(4):341-51 May 2013
邦文総説・著書
- 小林 拓 特集 クローン病小腸狭窄病変に対する内視鏡的バルーン拡張術─基本からピットフォールまで Ⅳ. 海外の文献を読み解く─ クローン病狭窄病変に対する切開法は有効か? INTESTINE Vol.24(3)256-258. 2020
- 小林 拓 炎症性腸疾患の新規治療薬とその適応─JAK阻害薬,抗IL-12/23抗体製剤,抗α4β7インテグリン抗体などはどのような薬剤でどのように使用するのか?─ Medical Practice 37(12)1917-1920. 2020
- 小林 拓 自己免疫疾患・膠原病・血管炎など Crohn病 消化器内視鏡 32巻増刊号 182-183. 2020
- 小林 拓 空腸,回腸,盲腸,結腸,直腸 (上) 消化管アミロイドーシス 日本臨床 別冊消化管症候群Ⅲ 190-193. 2020
- 小林 拓 炎症性腸疾患診療のupdate Ⅴ 炎症性腸疾患の内科治療 ⑨抗IL‒12 p40 抗体―ウステキヌマブ 臨床消化器内科 34(7)842-846. 2019
- 小林 拓、畑 啓介、尾崎 良、竹中 健人、石川 大 CDにおける抗TNFα抗体製剤の効果減弱 IBDクリニカルカンファレンス Vol.1 No.3 6-13. 2019
- 石橋とよみ、八木澤啓司、池上由佳、黒瀬由喜、小林 拓、日比紀文 ブテソニド注腸フォーム剤の受容性に関わる因子の検討 新薬と臨床 第67巻No.1(13-21) 2018
- 八木澤啓司、松原 肇、日比紀文 IBD患者指導のポイント:薬学的管理 月間薬事 Vol.60 No.1 66-70. 2018
- 日比紀文、松井敏幸、清水誠治 鼎談 腸間膜静脈硬化症-発症の実態と予後- PROGRESS IN MEDICINE 2月号38(175-182) 2018
- 原 勇輔、小林 拓、岡林慎二、中野 雅、佐上晋太郎、尾﨑 良、中山荘平、鈴木雄介、常松 令、日比紀文 結核スクリーニング検査が陰性であったにもかかわらず抗TNF-α抗体製剤導入後に肺結核を発症したクローン病の1例 日本消化器病学会雑誌 115(11)996-1003. 2018
- 小林 拓 連載「免疫病動物モデルの特長と限界」炎症性腸疾患動物モデル 炎症と免疫 26(2)162-166. 2018
- 小林 拓 特集/テーマ 病態から考え出されたIBD治療の進歩 Ⅳ.IL12/23阻害剤 INTESTINE Vol.22No.3 2018
- 小林 拓 「Real world practiceからみた接着分子阻害薬の炎症性腸疾患における今後の位置づけ」 消化器病学サイエンス 2(1): 29-32. 2018
- 小林 拓 V. 炎症性腸疾患の検査・診断2.炎症性腸疾患の診断における血液検査及び細菌学的検査 日本臨牀 76(増刊号3): 173-177. 2018
- 小林 拓 VI. 炎症性腸疾患の内科的治療3.炎症性腸疾患治療薬の使い方と特性(8)抗IL-12 p40抗体 日本臨牀 76(増刊号3): 345-349. 2018
- 岡林慎二, 小林拓, 日比紀文 IBD治療における免疫調節薬 (チオプリン製剤) の最適化 IBD Research 12(1): 12-17. 2018
- 小林 拓 序文 IBD Research 12(1)5. 2018
- 小林 拓 抗TNF-α抗体の止め方 IBD News 7月vol64.3. 2018
- 小林 拓 特集もっとうまくいく!病診連携の「伝え方」-わかりやすく伝えるための診療情報提供書作成のコツ第Ⅱ章<診療科別>コンサルトのポイントC.消化器科へコンサルト 2.炎症性腸疾患 臨床雑誌内科 122(3)527-530. 2018
- 小林 拓 特集 わが国のIBDの新規治療薬を網羅する!潰瘍性大腸炎に対する新規治療薬:ゴリムマブ IBD Research 12(3)147-150. 2018
- 小林 拓 炎症性腸疾患の内科治療 Medical Practice 35(12)1914-1918. 2018
- 日比紀文、石橋とよみ、八木澤啓司 注目の新薬 レクタブル®(ブデソニド) 診断と治療 106(9)1161-1164. 2018
- 梅田智子、芹澤宏、小林拓、豊永貴彦、齊藤詠子、中野雅、樋口肇、常松令、渡邊憲明、日比紀文、森永正二郎 腸管スピロヘータ症(human intestinal spirochetosis;HIS)の臨床的意義についての検討 日本消化器病学会雑誌 vol.114 no.2 230-237. 2017
- 日比紀文、小林 拓、久松理一 特集:炎症性腸疾患ー最近の診断・治療ーⅠ.総論 炎症性腸疾患の病態 日本臨床 75巻 月刊号3 別刷 2017/3/1
- 齊藤詠子、日比紀文 妊婦・授乳期における炎症性腸疾患治療薬の使い方 INTESTINE VOL.21 NO.2 2017
- 豊永貴彦、小林拓、齊藤詠子、岡林慎二、日比紀文 IBD患者のアドヒアランス不良例 IBD Research(別刷) vol.11 no.1 2017
- 日比紀文 炎症性腸疾患 検査と技術 vol.45 no.8 802-807. 2017
- 松岡克善、酒匂美奈子、高添正和、市川仁志、竹内義明、小林拓、渡辺守、日比紀文、金井隆典 日本人患者における便中カルプロテクチン検査の臨床的有用性 医学と薬学(別刷) 74(6)717-726. 2017
- 日比紀文 初版の序 IBDを日常診療で診る 4-5. 2017/2/1
- 日比紀文 特集:腸内細菌をめぐって(序説) INTESTINE vol.21,no.4 2017
- 日比紀文 炎症性腸疾患 アミノサリチル酸製剤,副腎皮質ステロイド プリンシプル消化器疾患の臨床2 腸疾患診療の現在 126-129. 2017
- 日比紀文 大腸検査での“炎症内視鏡”の役割 日本大腸検査学会雑誌 34(1)3-4. 2017/10
- 日比紀文 小林拓 ブテソニド注腸フォーム剤の受容性に関わる因子の検討 新薬と臨床 1月10日号 2018
- 日比紀文 炎症性腸疾患 検査と技術 vol.45 no.8 802-807 2017
- 日比紀文 他 日本人患者における便中カルプロテクチン検査の臨床的有用性 医学と薬学(別刷) 2017
- 日比紀文 小林拓 他 IBD患者のアドヒアランス不良例 IBD Research(別刷)vol.11 no.1 2017
- 日比紀文 他 妊婦・授乳期における炎症性腸疾患治療薬の使い方 INTESTINE VOL.21 NO.2 2017
- 日比紀文 IBDを日常診療で診る 4-5 羊土社 2017
- 日比紀文 小林拓 他 特集:炎症性腸疾患ー最近の診断・治療ーⅠ.総論 炎症性腸疾患の病態 日本臨床75巻 月刊号3 別刷 2017
- 日比紀文 きめ細やかなIBD治療をめざして IBD診療ビジュアルテキスト 14-16 羊土社 2016
- 小林拓 非特異性多発性小腸潰瘍症の難病指定とSLCO2A1関連小腸症 日本消化器病学会雑誌113(8)1380-1385 2016
- 小林拓 2週目のインフリキシマブトラフ濃度は寛解導入の予後を予測する INTESTINE 20(5):504-506 2016
- 小林拓 消化器良性疾患診療ガイドラインのポイント 潰瘍性大腸炎 2016
- 小林拓 抗TNF‐α抗体を「中止する」ときを見極めるポイント 薬局5月号 2016
- 日比紀文 小林拓 他 チオプリン系免疫調節薬による難治性潰瘍性大腸炎の治療戦略 IBD Research vol.10 no. 2 2016
- 小林拓 便潜血とカルプロテクチン INTESTINE 2016
- 小林拓 炎症性腸疾患治療の変遷―今後、治療はどう変わつていくのか― GI FOREFRONTvol. 12 no.1 2016
- 小林拓 他 潰瘍性大腸炎治療前後の画像(経時的) 炎症性腸疾患Imaging Atlas(日本メディカルセンター・東京)
- 日比紀文 小林拓 他 非特異性多発性小腸潰瘍症の難病指定とSLCO2A1 関連小腸症 日本消化器病学会8月;113(8):36-41 2016
- 日比紀文 特集 クローン病治療の最前線Ⅰどのような症例に抗TNF-α抗体製剤を使うべきか?INTESTINE20(2);127-132 2016
- 日比紀文 小林拓 他 特集 難治性潰瘍性大腸炎の適切な治療戦略を考える! チオプリン系免疫調節薬による難治性潰瘍性大腸炎の治療戦略 IBD Research 2016
- 日比紀文 小林拓 他 炎症性腸疾患患者における高張性腸管洗浄剤(モビプレップ®)の受容性、有効性、安全性の検討 日本大腸検査学会雑誌32(2);27(91)-34(98) 2016
- 日比紀文 日比紀文 聞いて納得!おくすりガイド 便秘の薬 NHKきょうの健康2月号 2016
- 日比紀文 日比紀文監修 チーム医療につなげる!IBD診療ビジュアルテキスト
- 日比紀文 IBD治療薬の選び方・使い方 監修の序 3-4 2015
- 日比紀文 単純性潰瘍/腸管ベーチェット病 G.I.Research Jun;23(3):68(252)-71(255) 2015
- 日比紀文 大腸の検査 別冊NHKきょうの健康 検査でわかること74-81 2015
- 日比紀文 小林拓 他 -炎症性腸疾患-ファーストタッチから長期マネジメントまで-炎症性腸疾患の診断、病型と重症度の判定 内科116(4);565-568 2015
- 日比紀文 小林拓 他 特集 炎症性腸疾患-病態研究から標的治療への展開- 日本から世界に発信する新しい診断・治療 最新醫學Feb;70(2):106(280)-111(285) 2015
- 日比紀文 小林拓 他 腸管ベーチェット病と単純性潰瘍の診断法や治療法は確立したか?分子消化器病Mar;12(1):43(43)-48(48) 2015
- 日比紀文 日本の消化器病学が世界をリードする?月刊 臨牀と研究Feb;92(2):1(3)-2(4) 2015
- 日比紀文 小林拓 小林拓「ステロイド抵抗例の次の一手」 IBD治療薬の選び方・使い方(日比紀文監修) 羊土社 2015
- 日比紀文 特集 腸管ベーチェット病と単純性潰瘍 腸管ベーチェット病の治療-改訂コンセンサスを中心に INTESTINE 2014
- 日比紀文 わたしの研究歴 G.I.Research 22(5):67(475)-70(478) 2014
- 日比紀文 実地診療における炎症性腸疾患 ドクターサロンvol.58 10月号 (729)9~(733)13 2014
- 日比紀文 小林拓 他 特集 生物学的製剤の適応があるリウマチ類縁疾患 炎症性腸疾患 2014
- 日比紀文 特集 ■エキスパートに学ぶ!薬物治療における直腸投与製剤の位置づけと活用のポイント-①潰瘍性大腸炎 薬局65(9):76(2426)-80(2430) 2014
- 日比紀文 特集「日常遭遇する大腸炎の鑑別-内視鏡を中心に」「序説」 INTESTINE18(4):329-330 2014
- 日比紀文 小林拓 内視鏡像の変化を観察可能であった原発性胃アミロイドーシスの1例 Progress of Digestive Endoscopy 第97回 日本消化器内視鏡学会関東地方会論文集Vol.84 No.1 88-89 2014
- 小林拓 潰瘍性大腸炎とクローン病は何がどう違うのか(1)免疫学的違いは?
Medicina 2014.6
- 小林拓、長沼誠、緒方晴彦、日比紀文、金井隆典 超拡大内視鏡 INTESTINE 2014.3
- 日比紀文、小林拓、中野雅 「潰瘍性大腸炎」 内科 Vol.113 No.6 2014
- 日比紀文、小林拓、中野雅 「潰瘍性大腸炎の内科治療-近年の変化」 日本成人病(生活習慣病)学会準機関誌 成人病と生活習慣病 44(3):311-315 2014
- 小林拓、筋野智久、加藤裕佳子、中野雅、日比紀文
IBD診療に使用されるインデックスの今後の展望 IBD Research 8(1):37-42 2014
- 小林拓、長沼誠、緒方晴彦、日比紀文、金井隆典
大腸内視鏡(4)超拡大内視鏡 INTESTINE 18(2):127-132 2014
- 小林拓 各治療の最適化とコツ-治療薬を使いこなす
「シクロスポリン(CSA)・タクロリムス(TAC)」実践!IBD診療 医学出版 2014.5
- 小林拓「Sporadicと判断し局所切除で治療した症例」IBD診療ケーススタディ
日本医事新報社 2013.10
- 小林拓 「シクロスポリンで治療した潰瘍性大腸炎症例」IBD診療ケーススタディ
日本医事新報社 2013.10
- 小林拓 University of North Carolinaでの研究生活 GI Research2014/02/先端医学社
- 小林拓 炎症性腸疾患治療の最新の話題 Annual Review消化器2013 中外医学社
- 小林拓、金井隆典 「クローン病とサイトカイン」臨床免疫・アレルギー科60(4)
- 小林拓 「専門医に聞く」IBD Research 2013.12月号 先端医学社
- Functional gastrointestinal disorders(FGID): progress in diagnosis and treatments. Topics: Ⅱ. Current status and future prospective of medical care of the representative disorders; 3. Functional dyspepsia. 日本内科学会雑誌102(1):63-9
- 水城啓、立道昌幸、鳩貝健、岩崎栄典、泉谷幹子、前田憲男、中澤敦、重松武治、塚田信廣、永田博司、日比紀文
大腸憩室出血に対する最適な内視鏡的処置法の検討 日本消化器病学会雑誌 110(11):1927-1933 2013
- 日比紀文、久松理一
炎症性腸疾患の病態解明と治療の進歩 日本内科学会雑誌 102(9);2195-2213 2013
- 桜庭篤、日比紀文
クローン病寛解維持での注射間隔の短縮による血清インフリキシマブレベルの回復は臨床的治療効果に相関する INTESTINE 17(5);526-527 2013
- 堀江義則、山岸由幸、海老沼浩利、日比紀文
アルコール性肝硬変、肝細胞癌における栄養障害の影響とその予防のための栄養学的なアプローチの提案 消化器内科 56(1):132-140 2013
- 日比紀文、久松理一
炎症性腸疾患の病態解明と治療の進歩 日本内科学会雑誌 102(9);2195-2213 2013
- 桜庭篤、日比紀文
クローン病寛解維持での注射間隔の短縮による血清インフリキシマブレベルの回復は臨床的治療効果に相関する INTESTINE 17(5);526-527 2013
- 松下美紗子、海老沼浩利、福原誠一郎、南和志、南一洋、中本伸宏、船越信介、金井隆典、齋藤英胤、日比紀文:Telaprevir/Peginterferon/Ribavirin3剤併用療法施行中に急性膵炎を発症し、Telaprevirの再投与により再燃を来たした1例 肝臓 54(5):340-346 2013
- 矢島知治、日比紀文:過敏性腸症候群の診断と治療 治療マニュアル 3・消化器 2013
- 久松理一、日比紀文:自然免疫と炎症性腸疾患 日本消化器病学会雑誌110(5):753-763 2013
- 鈴木秀和、西澤敏宏、日比紀文:機能性消化管障害(FGID):診断と治療の進歩 Ⅱ代表的疾患の診療の現況と将来展望 3.機能性ディスペプシア 日本内科学会雑誌 102(1):63-9 2013
- 正岡建洋、鈴木秀和、日比紀文:機能性胸やけ・RomeⅢ分類について Medicina50(5):836-838 2013
- 久松理一、米野和明、日比紀文:ここまで進んだ潰瘍性大腸炎の治療
東京内科医会会誌28(3):258-262 2013
学会発表
国際学会
- Recommendations on abdominal ultrasound in inflammatory bowel disease (20-min pre-recorded presentation video) AOCC2021 Oct 14-16, 2021. Kobayashi T
- Challenge case III (20-min pre-recorded presentation video) AOCC2021 Oct 14-16, 2021. Kobayashi T
- IL-1R-mediated mechanisms of IL-10 production by gut macrophages. AOCC2021 Oct 14-16, 2021. Hibi N et al
- Predicting risk factors of steroid dependence after initial steroid therapy in ulcerative colitis. AOCC2021 Oct 14-16, 2021. Miyatani Y et al
- Usefulness of colestimide for postoperative refractory diarrhea in patients with Crohn's disease. AOCC2021 Oct 14-16, 2021. Hojo A et al
- Sustained Reduction of IL-23-Related Cytokines IL-17A and IL-22 in a Phase 2 Study of Mirikizumab in the Treatment of Patients With Moderately-to-Severely Active Ulcerative Colitis. ECCO2020 Feb 12-17, 2020. Kobayashi T et al
- Session Abbvie Esai Korea Inc.sponsored symposium1 “Evidence to support optimal IBD management in clinical practice.” AOCC2020 Dec 12.16-18, 2020. Kobayashi T
- Optimal therapeutic strategies: thinking out of the box De-escalation of therapy in patients with quiescent IBD. AOCC2020 Dec 12.16-18, 2020. Kobayashi T
- Capsule scoring of ulcerative colitis (CSUC) is useful for monitoring inactive ulcerative colitis. Crohn's and colitis congress 2019 Feb 7-11, 2019. Matsubayashi M et al
- Accuracy of Doppler transabdominal ultrasound in assessing disease severity and extent in IBD. ECCO2019 Mar 7, 2019. Sagami S et al
- Withdrawal of thiopurines in Crohn’s disease treated with scheduled adalimumab maintenance: a prospective randomised clinical trial (DIAMOND2) ECCO2019 Mar 7, 2019. Hibi T et al
- Safety and effectiveness of adalimumab treatment in 1523 patients with ulcerative colitis: Results from a prospective, multi-centre ,observational study. ECCO2019 Mar 7, 2019. Hibi T et al
- Scientific Session 5: IBD around the world. ECCO2019 Mar 8, 2019. Hibi T (Chair)
- Extended induction treatment with mirikizumab in patients with moderately to severely active ulcerative colitis: results from a Phase 2 trial. ECCO2019 Mar 8, 2019. Hibi T et al
- Amiselimod, a selective S1P receptor modulator in Crohn’s disease patients: a proof-of-concept study. ECCO2019 Mar 8, 2019. Hibi T et al
- Maintenance treatment with mirikizumab, a p19-directed IL-23 antibody: 52-week results in patients with moderately-to-severely active ulcerative colitis. ECCO2019 Mar 9, 2019 Hibi T et al
- Does switching between 5-aminosalicylates affest thiopurine metabolism and clinical outcomes in patients with ulcerative colitis? Digestive Disease Week 2019 San Diego May 18-21, 2019. Hibi T,Kobayashi T et al
- Capsule Endoscopy for IBD Plenary Session 1(Diagnosis of IBD) AOCC2019台北(台湾) Jun 14-16, 2019. Kobayashi T
- Clinical characteristics and outcomes of 5-ASA intolerance in patients with ulcerative colitis. AOCC2019台北(台湾) Jun 14-16, 2019. Kiyohara H et al
- Efficacy and safety of anti-fractalkine monoclonal antibody,E6011,in patients with Crohn's Disease who had lost response to anti-TNFa agents: A multicentre,open-label,Phase 1/2 study. ECCO2018 Feb 16, 2018. Hibi T et al
- Incidence risks of colorectal cancer, non-melanoma skin cancers, and non-Hodgkin lymphoma in Japanese patients with ulcerative colitis based on a large-scale claims database. ECCO2018 Feb 16, 2018. Hibi T,Kobayashi T et al
- “Risks of malignancies in Japanese patients with ulcerative colitis based on the large-scale claims databases” ECCO2018 Feb 19, 2018. Kobayashi T
- Challenging case II. 6th annual meeting of Asian Organization for Crohn’s and Colitis Jun 22, 2018. Kobayashi T
- Mechanism-based treatment strategy for IBD: How to use new medicines properly “JAK inhibitors” FALK symposium 212 Sep 7-8, 2018 Kobayashi T
- Clinical characteristics and outcomes of 5-ASA intolerance in patients with ulcerative colitis. FALK symposium 212 Sep 7-8, 2018. Kiyohara H et al
- Accuracy of transabdominal ultrasound in assessing disease activity in ulcerative colitis. FALK symposium 212 Sep 7-8, 2018. Hibi T,Kobayashi T et al
- Emerging Therapies in IBD “New kids on the block” the role of small molecules in IBD. The 3rd APAGE Clinical IBD Forum Cebu 2018 Sep 22, 2018. Kobayashi T
- High-fat low-carbohydrate diet influence the intestinal tract and microbiota of mice. CEBU 2018 3rd APAGE Clinical Forum on IBD Sep 22, 2018. Kuronuma S et al
- Different genetic aspects of IBD in Asia. The 5th IBD Summit Forum Dalian,China Nov 25-56, 2017. Hibi T
- Association between pharmacokinetics of adalimumab and disease outcome in Japanese patients with biologics naive Crohn’s Disease: A subanalysis of DIAMOND trial. Feb 15-18, 2017. Hibi et al
- Efficacy of anti-TNF for internal fistula in Crohn’s Disease – results from a retrospective multicenter cohort study.ECCO2017 Feb 15-18, 2017. Hibi,Kobayashi et al
- Combination therapy with adalimumab and immunomodulators decreases incidence of intestinal resection in Crohn’s Disease patients previously treated with infliximab: A large,multicentre cohort study.ECCO2017 Feb 15-18, 2017. Hibi,Kobayashi et al
- Histological risk factors to predict clinical relapse in Ulcerative Colitis in mucosal healing.ECCO2017 Feb 15-18, 2017. Hibi,Kobayashi et al
- Clinical features of chronic enteropathy associated with SLCO2A1 gene (CEAS)ECCO2017 Feb 15-18, 2017. Hibi et al
- Submucosal injection of the oligonucleotide STNM01 is able to induce clinical remission,mucosal healing and histological response in left-sided Ulcerative Colitis patients with Moderate-to-Severe disease. ECCO2017 Feb 17, 2017. Hibi et al
- Comparison of endoscopic responses to adalimumab monotherapy and combination therapy with azathioprine in patients with Crohn's Disease:A sub-analysis of DIAMOND trial.ECCO2017 Feb 17, 2017. Hibi et al
- Usefulness of fecal calprotectin in detecting the early response to induction therapy in ulcerative colitis. ACG 2016, Las Vegas, USA, Oct 18 (poster) Oct 18,2016 Kobayashi
- Adalimumab 80 mg Every Other Week in Japanese Patients with Crohn's Disease Who Lost Response to Maintenance Therapy.AOCC2016 Jul 9, 2016. Hibi et al
- Efficacy and safety of golimumab subcutaneous administration in Japanese patients with moderately to severely active ulcerative colitis.AOCC2016 Jul 9, 2016. Hibi et al
- Effects of CYP3A5 genotype on efficacy and safety of tacrolimus in refractory ulcerative colitis-experience from a tertiary referral center.AOCC2016 Jul 9, 2016. Hibi,Kobayashi et al
- Chronic enteropathy associated with SLCO2A1 gene,encoding prostaglandin transporter(CEAS):relationship with primary hypertrophic osteoarthropathy.AOCC2016 Jul 9, 2016. Hibi et al
- Factors associated with the first trough level of infliximab at week 2 that predicts short- and long-term outcomes.DDW2016, San Diego, USA May 21, 2016. Hibi,Kobayashi et al
- What do we know about the impact of nutrients on the mucosal immune system?Asia America Assembly of IBD Apl 7, 2016. Hibi,Kobayashi et al
- Faecal calprotectin and S100A12 detect the early response to treatment by quantifying colonic inflammation in patients with Ulcerative Colitis.11th Congress of ECCO RAI Amsterdam Mar 16-19, 2016. Hibi,Kobayashi et al
- Factors associated with the first trough level of infliximab at week 2 that predicts short-and long-term outcomes in Ulcerative Colitis. 11th Congress of ECCO RAI Amsterdam Mar 19, 2016. Hibi,Kobayashi et al
- Mid-to long-term stability and associated prognostic factors of adalimumab treatment for 1189 patients with Crohn's Disease:A multicentre cohort study.11th Congress of ECCO RAI Amsterdam Mar 18, 2016. Hibi,Kobayashi et al
- Comparison of adalimumab monotherapy and a combination with azathioprine for patients with Crohn's Disease: A prospective,multicentre,open-labeled clinical trial (DIAMOND study).11th Congress of ECCO RAI Amsterdam Mar 18, 2016. Hibi et al
- First Trough Level of Infliximab at Week 2 Predicts Future Outcomes of Induction Therapy in Icerative Colitis: A Post-hoc Analysis of a Multicenter Prospective Randomized Controlled Trial . ACG2015 Oct 20, 2015. Hibi,Kobayashi et al
- Usefulness of fecal S100A12 in defining mucosal healing in ulcerative colitis. 3rd AOCC, Beijing, China June 20, 2015. Kobayashi
- Infliximab therapy for Japanese patients with Ulcerative Colitis : Efficacy,safety,and association between serum infliximab levels and early respnse in a randomized, double-blind,placebo-controlled study.10th Congress of ECCO CCIB Barcelona Feb 18-21, 2015. Hibi et al
- Twice-daily budesonide rectal foam induces complete mucosal healing in Japanese patients with mild to moderate Ulcerative Colitis : Results of multicentre, randomised, double-blind,placebo-controlled trial.10th Congress of ECCO CCIB Barcelona Feb 18-21, 2015. Hibi et al
- Impact of Inflammatory Bowel Disease on Japanese patients` lives : International comparison of patients` views.10th Congress of ECCO CCIB Barcelona Feb 18-21, 2015 Hibi et al
- Usefulness of faecal S100A12 in defining mucosal healing in Ulcerative Colitis.10th Congress of ECCO CCIB Barcelona Feb 18-21, 2015. Hibi,Kobayashi et al
- A large-scale, prospective, observational study of leukocytapheresis for ulcerative colitis: Treatment outcomes of 847 patients in clinical practice. 2nd AOCC, Seoul, June 20, 2014. Kobayashi et al
- 「(tentative)How to use IFX in UC in 2014?The need for new treatment algorithms」FEBG UC Expert Meeting 2014 In Chicago May 6, 2014. Hibi(chair)
- Anti-TNFs in UC: who,when,how?FEBG UC Expert Meeting May 6, 2014. Hibi(chair)
- Timely use of biologics in UC.UC Seminar 2014 in Chicago May 5, 2014. Hibi(chair)
- How to manage UC in a Long term perspective.(Draft) Lecture meeting at DDW May 4, 2014. Hibi(chair)
- Efficacy, Safety, and Demographics Factor of Adalimumab Therapy in 1693 Japanese Crohn's Disease Patients.DDW Chicago May 3-6, 2014. Hibi et al
- Percutaneous Endoscopic Gastrostomy Under Steady Pressure Automatically Controlled Endoscopy. (SPACE)DDW Chicago May 3-6, 2014. Hibi et al
- Efficacy and Safety of Rikkunshito, a Japanese Herbal Medicine, on the Treatment of Functional Dyspepsia: A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study.DDW Chicago May 3-6, 2014. Hibi et al
- AJM300, an Oral α4 Integrin Antagonist, for Active Ulcerative Colitis: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2A Study.DDW Chicago May 3-6, 2014. Hibi et al
- Current and future treatments of IBD in Japan Are they different from Westerns?PUMCH International Digestive Disease Forum Apl 19, 2014. Hibi
- Feasibility of the second-generation colon capsule endoscopy in patients with ulcerative colitis with a reduced preparation regimen. 1st AOCC, Tokyo, June 14, 2013. (Oral) Kobayashi et al
- NFIL3 deficient mice develop IL-12/23 driven spontaneous colitis. 1st AOCC, Tokyo,June 13, 2013. (Oral) Kobayashi et al
- Feasibility of the second-generation colon capsule endoscopy in patients with ulcerative colitis with a reduced preparation regimen. DDW2013, Orlando, FL, May 20, 2013. (Poster) Kobayashi et al
- Amino acids and inflammatory bowel disease-as a therapeutic target and a novel biomarker. 8th Asia Pacific Conference, Tokyo, June 10, 2013. Hibi
- The future perspective and issues of IBD in Asia, 1th AOCC, Tokyo, June 13-14, 2013. Hibi
- Diffrences between treatment guidelines in IBD, Falk Symposium 188, Germany, June 8, 2013. Hibi
国内学会
賞罰・研究助成
- 厚生労働科学研究費補助金難治性炎症性腸管障害に関する調査研究「難治性炎症性腸管障害に関する調査研究」分担研究者(2020-2022) 小林拓
- 日本医療研究開発機構免疫アレルギー疾患等実用化研究事業「家族性地中海熱関連腸炎の診断法確立と病態解明を目指す研究」分担研究者(2019-2021) 小林拓
- 日本応用酵素協会(2021) 宮谷侑佑
- 日本応用酵素協会(2020) 黒沼智
- 内藤記念特定研究助成金(2019) 日比紀文
- 日本応用酵素協会(2019) 日比則孝
- 科研費(基盤C)分担研究者(2017-2019) 小林拓
- 日本応用酵素協会(2018) 森久保拓
- 日本応用酵素協会(2017) 佐上晋太郎
- 内視鏡医学研究振興財団助成金B (2017) 小林拓
- 厚生労働科学特別研究事業「潰瘍性大腸炎患者に対する青黛治療の有害事象実態調査と機序解明」分担研究者(2017) 日比紀文
- 厚生労働科学研究委託費革新的医療技術創出拠点プロジェクト関連シーズ「インフリキシマブ治療抵抗性クローン病患者を対象としたアドレノメデュリン製剤による医師主導治験の実施」分担研究者(2017~2019) 日比紀文
- 厚生労働科学研究委託費難治性疾患等実用化研究事業「炎症性腸疾患における食関連リスク因子に関する研究」分担研究者(2016~2018) 日比紀文 小林拓
- 東京生化学研究会(2016) 日比紀文
- 日本応用酵素協会(2016) 岡林慎二
- 第30回日本消化器病学会奨励賞 (2016) 小林拓
- 科研費基盤C (2016-18) 小林拓
- Best Abstract Award at 3rd AOCC (2015) 小林拓
- 東京生化学研究会(2015) 日比紀文
- 日本応用酵素協会(2015) 黒沼 智
- 厚生労働科学研究委託費難治性疾患等実用化研究事業「独自の体外病態モデルによる難治性炎症性腸疾患の革新的治療薬開発に関する研究」分担研究者(平成26年~28年度) 日比紀文
- 厚生労働科学研究委託費難治性疾患等実用化研究事業「難治性小腸潰瘍の診断法確立と病態解明に基づいた治療法探索」分担研究者(平成26~28年度) 日比紀文
- 日本応用酵素協会(2014) 小林拓 豊永貴彦
- Discinct Abstract Award at 2nd AOCC(2014) 小林拓
- 消化器病学会研究助成金 小林拓
- 科研費(基盤C)(2013-15)小林拓
- 研究助成金(B)内視鏡医学振興財団2013 小林拓
- 上原記念生命医学財団平成25年度研究奨励金(2013)小林拓
- 厚生労働科学研究費補助金難治性疾患克服研究事業 「腸管希少難病群の疫学、病態、診断の相同性と相違性から見た包括的研究」
主任研究者(平成24年度~25年度) 日比紀文
- 厚生労働科学研究費補助金難治性疾患克服研究事業 「難治性炎症性腸管障害に関する調査研究」分担研究者(2010〜13) 日比紀文
- Best Oral Award at 1 st AOCC(2013) 小林拓
- 平成25年度ACG International Leadership Award 日比紀文
- 日本応用酵素協会(2013) 筋野智久
- 日本応用酵素協会(2012) 小林拓